Suppressors of cytokine signaling (SOCS) proteins and JAK/STAT pathways: Regulation of T-cell inflammation by SOCS1 and SOCS3

Taiga Tamiya, Ikko Kashiwagi, Reiko Takahashi, Hideo Yasukawa, Akihiko Yoshimura

Research output: Contribution to journalArticle

208 Citations (Scopus)

Abstract

Various cytokines are involved in the regulation of the immune system and inflammation. Dysregulation of cytokine signaling can cause a variety of diseases, including allergy, autoimmune diseases, inflammation, and cancer. Most cytokines use the so-called janus kinase/signal transducer and activator of transcription pathway, and this pathway is negatively regulated by suppressors of cytokine signaling (SOCS) proteins. SOCS proteins bind to janus kinase and to certain cytokine receptors and signaling molecules, thereby suppressing further signaling events. Studies have shown that SOCS proteins are key physiological regulators of inflammation. Recent studies have also demonstrated that SOCS1 and SOCS3 are important regulators of adaptive immunity.

Original languageEnglish
Pages (from-to)980-985
Number of pages6
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume31
Issue number5
DOIs
Publication statusPublished - 2011 May 1

Keywords

  • cytokines
  • immune system
  • leukocytes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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