Surgical outcome of stage IIIA- cN2/pN2 Non-Small-Cell lung cancer patients in japanese lung cancer registry study in 2004

Ichiro Yoshino, Shigetoshi Yoshida, Etsuo Miyaoka, Hisao Asamura, Hiroaki Nomori, Yoshitaka Fujii, Yoichi Nakanishi, Kenji Eguchi, Masaki Mori, Noriyoshi Sawabata, Meinoshin Okumura, Kohei Yokoi

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background: The role of surgery in the treatment of non-small-cell lung cancer (NSCLC) with clinically manifested mediastinal node metastasis is controversial even in resectable cases because it is often accompanied by systemic micrometastasis. However, surgery is occasionally indicated for cases with single-station N2 disease or within multimodal treatment regimens, and in clinical trials. The aim of this study is to evaluate surgical outcomes in a modern cohort of patients with clinical (c-) stage IIIA-N2 NSCLC whose nodal metastasis was confirmed by pathology (cN2/pN2). Methods: From the central database of lung cancer patients undergoing surgery in 2004, which was founded by the Japanese Joint Committee for Lung Cancer Registration, data of patients having all conditions of NSCLC, c-stage IIIA, cN2, and pN2 were extracted, and the clinicopathologic profile of patients and surgical outcomes were evaluated. Results: Among 11,663 registered NSCLC cases, 436 patients (3.8%) (332 men and 104 women) had been extracted. Their mean age was 65 years, and histologic types included adenocarcinoma (n = 246), squamous cell carcinoma (n = 132), and others (n = 58). The proportion of R0 resection was 82.5% and the proportion of the hospital deaths among the cause of death was 2.3%. The 5-year survival rate was 30.1% for the selected group of patients. The postoperative prognosis was significantly better than those of corresponding populations extracted from the 1994 (p = 0.0001) and 1999 databases (p = 0.0411). Men and women experienced a significantly different survival outcome (p = 0.025) with 5-year survivals of 27.5% and 37.8%, respectively. Single-station N2 cases occupied 60.9 % of the cohort and showed a significantly better prognosis than multistation N2 (p = 0.0053, 35.8 % versus 22.0 % survival rate at 5 years). Conclusions: The surgical outcomes of c-stage IIIA-cN2/pN2 NSCLC patients in 2004 were favorable in comparison with those ever reported.

Original languageEnglish
Pages (from-to)850-855
Number of pages6
JournalJournal of Thoracic Oncology
Volume7
Issue number5
DOIs
Publication statusPublished - 2012
Externally publishedYes

Fingerprint

Non-Small Cell Lung Carcinoma
Registries
Lung Neoplasms
Survival Rate
Databases
Neoplasm Metastasis
Combined Modality Therapy
Neoplasm Micrometastasis
Survival
Cause of Death
Squamous Cell Carcinoma
Adenocarcinoma
Clinical Trials
Pathology
Population

Keywords

  • Mediastinal node metastasis
  • Non-small-cell lung cancer
  • Surgery

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine

Cite this

Surgical outcome of stage IIIA- cN2/pN2 Non-Small-Cell lung cancer patients in japanese lung cancer registry study in 2004. / Yoshino, Ichiro; Yoshida, Shigetoshi; Miyaoka, Etsuo; Asamura, Hisao; Nomori, Hiroaki; Fujii, Yoshitaka; Nakanishi, Yoichi; Eguchi, Kenji; Mori, Masaki; Sawabata, Noriyoshi; Okumura, Meinoshin; Yokoi, Kohei.

In: Journal of Thoracic Oncology, Vol. 7, No. 5, 2012, p. 850-855.

Research output: Contribution to journalArticle

Yoshino, I, Yoshida, S, Miyaoka, E, Asamura, H, Nomori, H, Fujii, Y, Nakanishi, Y, Eguchi, K, Mori, M, Sawabata, N, Okumura, M & Yokoi, K 2012, 'Surgical outcome of stage IIIA- cN2/pN2 Non-Small-Cell lung cancer patients in japanese lung cancer registry study in 2004', Journal of Thoracic Oncology, vol. 7, no. 5, pp. 850-855. https://doi.org/10.1097/JTO.0b013e31824c945b
Yoshino, Ichiro ; Yoshida, Shigetoshi ; Miyaoka, Etsuo ; Asamura, Hisao ; Nomori, Hiroaki ; Fujii, Yoshitaka ; Nakanishi, Yoichi ; Eguchi, Kenji ; Mori, Masaki ; Sawabata, Noriyoshi ; Okumura, Meinoshin ; Yokoi, Kohei. / Surgical outcome of stage IIIA- cN2/pN2 Non-Small-Cell lung cancer patients in japanese lung cancer registry study in 2004. In: Journal of Thoracic Oncology. 2012 ; Vol. 7, No. 5. pp. 850-855.
@article{719b1832afcd4f3eb22bb8c2e79ea134,
title = "Surgical outcome of stage IIIA- cN2/pN2 Non-Small-Cell lung cancer patients in japanese lung cancer registry study in 2004",
abstract = "Background: The role of surgery in the treatment of non-small-cell lung cancer (NSCLC) with clinically manifested mediastinal node metastasis is controversial even in resectable cases because it is often accompanied by systemic micrometastasis. However, surgery is occasionally indicated for cases with single-station N2 disease or within multimodal treatment regimens, and in clinical trials. The aim of this study is to evaluate surgical outcomes in a modern cohort of patients with clinical (c-) stage IIIA-N2 NSCLC whose nodal metastasis was confirmed by pathology (cN2/pN2). Methods: From the central database of lung cancer patients undergoing surgery in 2004, which was founded by the Japanese Joint Committee for Lung Cancer Registration, data of patients having all conditions of NSCLC, c-stage IIIA, cN2, and pN2 were extracted, and the clinicopathologic profile of patients and surgical outcomes were evaluated. Results: Among 11,663 registered NSCLC cases, 436 patients (3.8{\%}) (332 men and 104 women) had been extracted. Their mean age was 65 years, and histologic types included adenocarcinoma (n = 246), squamous cell carcinoma (n = 132), and others (n = 58). The proportion of R0 resection was 82.5{\%} and the proportion of the hospital deaths among the cause of death was 2.3{\%}. The 5-year survival rate was 30.1{\%} for the selected group of patients. The postoperative prognosis was significantly better than those of corresponding populations extracted from the 1994 (p = 0.0001) and 1999 databases (p = 0.0411). Men and women experienced a significantly different survival outcome (p = 0.025) with 5-year survivals of 27.5{\%} and 37.8{\%}, respectively. Single-station N2 cases occupied 60.9 {\%} of the cohort and showed a significantly better prognosis than multistation N2 (p = 0.0053, 35.8 {\%} versus 22.0 {\%} survival rate at 5 years). Conclusions: The surgical outcomes of c-stage IIIA-cN2/pN2 NSCLC patients in 2004 were favorable in comparison with those ever reported.",
keywords = "Mediastinal node metastasis, Non-small-cell lung cancer, Surgery",
author = "Ichiro Yoshino and Shigetoshi Yoshida and Etsuo Miyaoka and Hisao Asamura and Hiroaki Nomori and Yoshitaka Fujii and Yoichi Nakanishi and Kenji Eguchi and Masaki Mori and Noriyoshi Sawabata and Meinoshin Okumura and Kohei Yokoi",
year = "2012",
doi = "10.1097/JTO.0b013e31824c945b",
language = "English",
volume = "7",
pages = "850--855",
journal = "Journal of Thoracic Oncology",
issn = "1556-0864",
publisher = "International Association for the Study of Lung Cancer",
number = "5",

}

TY - JOUR

T1 - Surgical outcome of stage IIIA- cN2/pN2 Non-Small-Cell lung cancer patients in japanese lung cancer registry study in 2004

AU - Yoshino, Ichiro

AU - Yoshida, Shigetoshi

AU - Miyaoka, Etsuo

AU - Asamura, Hisao

AU - Nomori, Hiroaki

AU - Fujii, Yoshitaka

AU - Nakanishi, Yoichi

AU - Eguchi, Kenji

AU - Mori, Masaki

AU - Sawabata, Noriyoshi

AU - Okumura, Meinoshin

AU - Yokoi, Kohei

PY - 2012

Y1 - 2012

N2 - Background: The role of surgery in the treatment of non-small-cell lung cancer (NSCLC) with clinically manifested mediastinal node metastasis is controversial even in resectable cases because it is often accompanied by systemic micrometastasis. However, surgery is occasionally indicated for cases with single-station N2 disease or within multimodal treatment regimens, and in clinical trials. The aim of this study is to evaluate surgical outcomes in a modern cohort of patients with clinical (c-) stage IIIA-N2 NSCLC whose nodal metastasis was confirmed by pathology (cN2/pN2). Methods: From the central database of lung cancer patients undergoing surgery in 2004, which was founded by the Japanese Joint Committee for Lung Cancer Registration, data of patients having all conditions of NSCLC, c-stage IIIA, cN2, and pN2 were extracted, and the clinicopathologic profile of patients and surgical outcomes were evaluated. Results: Among 11,663 registered NSCLC cases, 436 patients (3.8%) (332 men and 104 women) had been extracted. Their mean age was 65 years, and histologic types included adenocarcinoma (n = 246), squamous cell carcinoma (n = 132), and others (n = 58). The proportion of R0 resection was 82.5% and the proportion of the hospital deaths among the cause of death was 2.3%. The 5-year survival rate was 30.1% for the selected group of patients. The postoperative prognosis was significantly better than those of corresponding populations extracted from the 1994 (p = 0.0001) and 1999 databases (p = 0.0411). Men and women experienced a significantly different survival outcome (p = 0.025) with 5-year survivals of 27.5% and 37.8%, respectively. Single-station N2 cases occupied 60.9 % of the cohort and showed a significantly better prognosis than multistation N2 (p = 0.0053, 35.8 % versus 22.0 % survival rate at 5 years). Conclusions: The surgical outcomes of c-stage IIIA-cN2/pN2 NSCLC patients in 2004 were favorable in comparison with those ever reported.

AB - Background: The role of surgery in the treatment of non-small-cell lung cancer (NSCLC) with clinically manifested mediastinal node metastasis is controversial even in resectable cases because it is often accompanied by systemic micrometastasis. However, surgery is occasionally indicated for cases with single-station N2 disease or within multimodal treatment regimens, and in clinical trials. The aim of this study is to evaluate surgical outcomes in a modern cohort of patients with clinical (c-) stage IIIA-N2 NSCLC whose nodal metastasis was confirmed by pathology (cN2/pN2). Methods: From the central database of lung cancer patients undergoing surgery in 2004, which was founded by the Japanese Joint Committee for Lung Cancer Registration, data of patients having all conditions of NSCLC, c-stage IIIA, cN2, and pN2 were extracted, and the clinicopathologic profile of patients and surgical outcomes were evaluated. Results: Among 11,663 registered NSCLC cases, 436 patients (3.8%) (332 men and 104 women) had been extracted. Their mean age was 65 years, and histologic types included adenocarcinoma (n = 246), squamous cell carcinoma (n = 132), and others (n = 58). The proportion of R0 resection was 82.5% and the proportion of the hospital deaths among the cause of death was 2.3%. The 5-year survival rate was 30.1% for the selected group of patients. The postoperative prognosis was significantly better than those of corresponding populations extracted from the 1994 (p = 0.0001) and 1999 databases (p = 0.0411). Men and women experienced a significantly different survival outcome (p = 0.025) with 5-year survivals of 27.5% and 37.8%, respectively. Single-station N2 cases occupied 60.9 % of the cohort and showed a significantly better prognosis than multistation N2 (p = 0.0053, 35.8 % versus 22.0 % survival rate at 5 years). Conclusions: The surgical outcomes of c-stage IIIA-cN2/pN2 NSCLC patients in 2004 were favorable in comparison with those ever reported.

KW - Mediastinal node metastasis

KW - Non-small-cell lung cancer

KW - Surgery

UR - http://www.scopus.com/inward/record.url?scp=84862145926&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862145926&partnerID=8YFLogxK

U2 - 10.1097/JTO.0b013e31824c945b

DO - 10.1097/JTO.0b013e31824c945b

M3 - Article

C2 - 22481238

AN - SCOPUS:84862145926

VL - 7

SP - 850

EP - 855

JO - Journal of Thoracic Oncology

JF - Journal of Thoracic Oncology

SN - 1556-0864

IS - 5

ER -