Surgical outcomes of spinal cord astrocytomas

Masaya Nakamura, K. Chiba, K. Ishii, Y. Ogawa, H. Takaishi, Morio Matsumoto, Y. Toyama

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Study design:Retrospective case series.Objectives:To analyze prognostic factors for patients with spinal cord astrocytomas.Setting:Department of Orthopaedic Surgery, Keio University, Japan.Methods:Seven patients received total excisions (group T), eight underwent partial excisions (group P), and 15 had excisional biopsies (group B). Impacts of the tumor histological grade, the level of the tumor, the types of surgical interventions, and the use of adjuvant radiotherapies on the survival and functional outcomes of 30 patients (18 in low-grade and 12 high-grade malignancy tumors) were analyzed.Results:The survival rate of the low-grade malignancy group was significantly higher than that of the high-grade group. The survival rate of the patients with thoracic astrocytomas was significantly higher than those with cervical astrocytomas. In both the low- and high-grade groups, the survival rates in groups P/T were significantly higher than those in group B. In the low-grade group, five patients, whose preoperative functional statuses were classified as 'fair' or better, remained 'fair' or better after surgery. In the high-grade group, the postoperative functional statuses were classified as 'no change' or 'aggravated' in all except two patients. No significant difference in the survival rates was detected between patients with and without adjuvant radiotherapy.Conclusions: The tumor grade and the extent of tumor resection were significant prognostic factors for survival rate. In low-grade malignancy group, good motor function was retained when surgeries were performed before substantial neurological deterioration. The efficacy of postoperative radiotherapy has yet to be determined and needs further study.

Original languageEnglish
Pages (from-to)740-745
Number of pages6
JournalSpinal Cord
Volume44
Issue number12
DOIs
Publication statusPublished - 2006 Dec 3

Fingerprint

Astrocytoma
Spinal Cord
Survival Rate
Neoplasms
Adjuvant Radiotherapy
Orthopedics
Japan
Radiotherapy
Thorax
Retrospective Studies
Biopsy
Survival

Keywords

  • Astrocytomas
  • Prognosis
  • Surgical treatment

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Nakamura, M., Chiba, K., Ishii, K., Ogawa, Y., Takaishi, H., Matsumoto, M., & Toyama, Y. (2006). Surgical outcomes of spinal cord astrocytomas. Spinal Cord, 44(12), 740-745. https://doi.org/10.1038/sj.sc.3101932

Surgical outcomes of spinal cord astrocytomas. / Nakamura, Masaya; Chiba, K.; Ishii, K.; Ogawa, Y.; Takaishi, H.; Matsumoto, Morio; Toyama, Y.

In: Spinal Cord, Vol. 44, No. 12, 03.12.2006, p. 740-745.

Research output: Contribution to journalArticle

Nakamura, M, Chiba, K, Ishii, K, Ogawa, Y, Takaishi, H, Matsumoto, M & Toyama, Y 2006, 'Surgical outcomes of spinal cord astrocytomas', Spinal Cord, vol. 44, no. 12, pp. 740-745. https://doi.org/10.1038/sj.sc.3101932
Nakamura M, Chiba K, Ishii K, Ogawa Y, Takaishi H, Matsumoto M et al. Surgical outcomes of spinal cord astrocytomas. Spinal Cord. 2006 Dec 3;44(12):740-745. https://doi.org/10.1038/sj.sc.3101932
Nakamura, Masaya ; Chiba, K. ; Ishii, K. ; Ogawa, Y. ; Takaishi, H. ; Matsumoto, Morio ; Toyama, Y. / Surgical outcomes of spinal cord astrocytomas. In: Spinal Cord. 2006 ; Vol. 44, No. 12. pp. 740-745.
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