Surgical resection of lung adenocarcinoma after crizotinib treatment: Report of a case

Kaoru Kaseda, Ken Ichi Watanabe, Keisuke Asakura, Akio Kazama

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2 Citations (Scopus)


A 45-year-old female was diagnosed as having lung adenocarcinoma harboring an anaplastic lymphoma kinase (ALK) rearrangement, stage IV (T2bN3M1b). She was treated with crizotinib as second-line chemotherapy. The clinical stage after crizotinib treatment was ycT2aN0M0, stage IB. We performed a left lower lobectomy and lymph node dissection aimed at local control and pathological confirmation of the remaining tumor. The final pathological stage was ypT2aN2M0, stage IIIA with Ef 1b. To the best of our knowledge, this is the first case report of surgical resection in ALK rearrangement-positive lung adenocarcinoma after crizotinib treatment.

Original languageEnglish
Article number74
JournalWorld Journal of Surgical Oncology
Issue number1
Publication statusPublished - 2015 Feb 22
Externally publishedYes



  • Anaplastic lymphoma kinase
  • Crizotinib
  • Non-small cell lung cancer
  • Salvage surgery

ASJC Scopus subject areas

  • Surgery
  • Oncology

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