Surgical treatment of children blinded by Stevens-Johnson syndrome

Kazuo Tsubota, Jun Shimazaki

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

PURPOSE: The surgical treatment of severe Stevens-Johnson syndrome is considered to be very difficult, especially in children. However, ocular surface reconstruction is possible in certain cases. METHODS: We have performed ocular surface reconstruction by allogeneic corneal epithelial stem cell transplantation in four children blinded by Stevens-Johnson syndrome. RESULTS: Two cases failed, and the other two had excellent results. The successful cases had good lacrimal function and conjunctival epithelium, with clear corneal stroma and pathology limited to the superficial ocular tissue, whereas the failures did not. CONCLUSIONS: The successful ocular surface reconstruction has been stable for more than 1 year in two cases, suggesting that some patients with Stevens-Johnson syndrome are very good candidates for ocular surface reconstruction, especially when the patients have good tear function and healthy conjunctival epithelium.

Original languageEnglish
Pages (from-to)573-581
Number of pages9
JournalAmerican Journal of Ophthalmology
Volume128
Issue number5
DOIs
Publication statusPublished - 1999 Nov

Fingerprint

Stevens-Johnson Syndrome
Tears
Epithelium
Corneal Stroma
Therapeutics
Stem Cell Transplantation
Epithelial Cells
Pathology

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Surgical treatment of children blinded by Stevens-Johnson syndrome. / Tsubota, Kazuo; Shimazaki, Jun.

In: American Journal of Ophthalmology, Vol. 128, No. 5, 11.1999, p. 573-581.

Research output: Contribution to journalArticle

@article{e9d8546ff28d4fbfaca4d5bcc93dd1db,
title = "Surgical treatment of children blinded by Stevens-Johnson syndrome",
abstract = "PURPOSE: The surgical treatment of severe Stevens-Johnson syndrome is considered to be very difficult, especially in children. However, ocular surface reconstruction is possible in certain cases. METHODS: We have performed ocular surface reconstruction by allogeneic corneal epithelial stem cell transplantation in four children blinded by Stevens-Johnson syndrome. RESULTS: Two cases failed, and the other two had excellent results. The successful cases had good lacrimal function and conjunctival epithelium, with clear corneal stroma and pathology limited to the superficial ocular tissue, whereas the failures did not. CONCLUSIONS: The successful ocular surface reconstruction has been stable for more than 1 year in two cases, suggesting that some patients with Stevens-Johnson syndrome are very good candidates for ocular surface reconstruction, especially when the patients have good tear function and healthy conjunctival epithelium.",
author = "Kazuo Tsubota and Jun Shimazaki",
year = "1999",
month = "11",
doi = "10.1016/S0002-9394(99)00224-X",
language = "English",
volume = "128",
pages = "573--581",
journal = "American Journal of Ophthalmology",
issn = "0002-9394",
publisher = "Elsevier USA",
number = "5",

}

TY - JOUR

T1 - Surgical treatment of children blinded by Stevens-Johnson syndrome

AU - Tsubota, Kazuo

AU - Shimazaki, Jun

PY - 1999/11

Y1 - 1999/11

N2 - PURPOSE: The surgical treatment of severe Stevens-Johnson syndrome is considered to be very difficult, especially in children. However, ocular surface reconstruction is possible in certain cases. METHODS: We have performed ocular surface reconstruction by allogeneic corneal epithelial stem cell transplantation in four children blinded by Stevens-Johnson syndrome. RESULTS: Two cases failed, and the other two had excellent results. The successful cases had good lacrimal function and conjunctival epithelium, with clear corneal stroma and pathology limited to the superficial ocular tissue, whereas the failures did not. CONCLUSIONS: The successful ocular surface reconstruction has been stable for more than 1 year in two cases, suggesting that some patients with Stevens-Johnson syndrome are very good candidates for ocular surface reconstruction, especially when the patients have good tear function and healthy conjunctival epithelium.

AB - PURPOSE: The surgical treatment of severe Stevens-Johnson syndrome is considered to be very difficult, especially in children. However, ocular surface reconstruction is possible in certain cases. METHODS: We have performed ocular surface reconstruction by allogeneic corneal epithelial stem cell transplantation in four children blinded by Stevens-Johnson syndrome. RESULTS: Two cases failed, and the other two had excellent results. The successful cases had good lacrimal function and conjunctival epithelium, with clear corneal stroma and pathology limited to the superficial ocular tissue, whereas the failures did not. CONCLUSIONS: The successful ocular surface reconstruction has been stable for more than 1 year in two cases, suggesting that some patients with Stevens-Johnson syndrome are very good candidates for ocular surface reconstruction, especially when the patients have good tear function and healthy conjunctival epithelium.

UR - http://www.scopus.com/inward/record.url?scp=0032704958&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032704958&partnerID=8YFLogxK

U2 - 10.1016/S0002-9394(99)00224-X

DO - 10.1016/S0002-9394(99)00224-X

M3 - Article

VL - 128

SP - 573

EP - 581

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

SN - 0002-9394

IS - 5

ER -