Surgically resected solitary cavitary lung adenocarcinoma: Association between clinical, pathologic, and radiologic findings and prognosis

Yukio Watanabe, Masahiko Kusumoto, Akihiko Yoshida, Kenji Suzuki, Hisao Asamura, Koji Tsuta

Research output: Contribution to journalArticle

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Abstract

Background The incidence of cavitary lung adenocarcinoma has recently increased; despite this, little is known about its clinical features and prognosis. We, therefore, evaluated the clinicopathologic features and prognosis of this malignancy. Methods Between 1998 and 2007, 2,316 patients without preoperative chemotherapy or radiation therapy underwent surgical resection for primary lung adenocarcinoma. Among these cases, 143 (6.2%) were diagnosed as having cavitary adenocarcinoma based on high-resolution computed tomography scans and were enrolled in our study. Results Cavitary adenocarcinoma occurred more frequently in patients who were male (p < 0.001); who had a smoking history (p < 0.001), larger tumor size (p < 0.001), a tumor in the lower lobe (p < 0.001), lymph node metastasis (p = 0.02), advanced tumor stage (p = 0.04), postoperative recurrence (p < 0.01), and a papillary (p = 0.02) or solid predominant tumor pattern (p < 0.01); and who had vascular (p < 0.001), lymphatic (p = 0.04), or pleural invasion (p < 0.01). Kaplan-Meier analysis revealed that the overall and recurrence-free survival of patients with cavitary adenocarcinoma was significantly shorter than that of patients with noncavitary adenocarcinoma (p < 0.001). Multivariate analysis revealed that cavity formation was an independent prognostic factor in adenocarcinoma (p = 0.028). Conclusions Cavitary adenocarcinoma has worse prognostic clinicopathologic characteristics than noncavitary adenocarcinoma. Based on this finding, cavitary and noncavitary adenocarcinoma tumors should be considered separate entities.

Original languageEnglish
Pages (from-to)968-974
Number of pages7
JournalAnnals of Thoracic Surgery
Volume99
Issue number3
DOIs
Publication statusPublished - 2015 Mar 1
Externally publishedYes

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Adenocarcinoma
Neoplasms
Recurrence
Adenocarcinoma of lung
Kaplan-Meier Estimate
Blood Vessels
Radiotherapy
Multivariate Analysis
Lymph Nodes
Smoking
History
Tomography
Neoplasm Metastasis
Drug Therapy
Survival
Incidence

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine
  • Medicine(all)

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Surgically resected solitary cavitary lung adenocarcinoma : Association between clinical, pathologic, and radiologic findings and prognosis. / Watanabe, Yukio; Kusumoto, Masahiko; Yoshida, Akihiko; Suzuki, Kenji; Asamura, Hisao; Tsuta, Koji.

In: Annals of Thoracic Surgery, Vol. 99, No. 3, 01.03.2015, p. 968-974.

Research output: Contribution to journalArticle

Watanabe, Yukio ; Kusumoto, Masahiko ; Yoshida, Akihiko ; Suzuki, Kenji ; Asamura, Hisao ; Tsuta, Koji. / Surgically resected solitary cavitary lung adenocarcinoma : Association between clinical, pathologic, and radiologic findings and prognosis. In: Annals of Thoracic Surgery. 2015 ; Vol. 99, No. 3. pp. 968-974.
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AU - Suzuki, Kenji

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N2 - Background The incidence of cavitary lung adenocarcinoma has recently increased; despite this, little is known about its clinical features and prognosis. We, therefore, evaluated the clinicopathologic features and prognosis of this malignancy. Methods Between 1998 and 2007, 2,316 patients without preoperative chemotherapy or radiation therapy underwent surgical resection for primary lung adenocarcinoma. Among these cases, 143 (6.2%) were diagnosed as having cavitary adenocarcinoma based on high-resolution computed tomography scans and were enrolled in our study. Results Cavitary adenocarcinoma occurred more frequently in patients who were male (p < 0.001); who had a smoking history (p < 0.001), larger tumor size (p < 0.001), a tumor in the lower lobe (p < 0.001), lymph node metastasis (p = 0.02), advanced tumor stage (p = 0.04), postoperative recurrence (p < 0.01), and a papillary (p = 0.02) or solid predominant tumor pattern (p < 0.01); and who had vascular (p < 0.001), lymphatic (p = 0.04), or pleural invasion (p < 0.01). Kaplan-Meier analysis revealed that the overall and recurrence-free survival of patients with cavitary adenocarcinoma was significantly shorter than that of patients with noncavitary adenocarcinoma (p < 0.001). Multivariate analysis revealed that cavity formation was an independent prognostic factor in adenocarcinoma (p = 0.028). Conclusions Cavitary adenocarcinoma has worse prognostic clinicopathologic characteristics than noncavitary adenocarcinoma. Based on this finding, cavitary and noncavitary adenocarcinoma tumors should be considered separate entities.

AB - Background The incidence of cavitary lung adenocarcinoma has recently increased; despite this, little is known about its clinical features and prognosis. We, therefore, evaluated the clinicopathologic features and prognosis of this malignancy. Methods Between 1998 and 2007, 2,316 patients without preoperative chemotherapy or radiation therapy underwent surgical resection for primary lung adenocarcinoma. Among these cases, 143 (6.2%) were diagnosed as having cavitary adenocarcinoma based on high-resolution computed tomography scans and were enrolled in our study. Results Cavitary adenocarcinoma occurred more frequently in patients who were male (p < 0.001); who had a smoking history (p < 0.001), larger tumor size (p < 0.001), a tumor in the lower lobe (p < 0.001), lymph node metastasis (p = 0.02), advanced tumor stage (p = 0.04), postoperative recurrence (p < 0.01), and a papillary (p = 0.02) or solid predominant tumor pattern (p < 0.01); and who had vascular (p < 0.001), lymphatic (p = 0.04), or pleural invasion (p < 0.01). Kaplan-Meier analysis revealed that the overall and recurrence-free survival of patients with cavitary adenocarcinoma was significantly shorter than that of patients with noncavitary adenocarcinoma (p < 0.001). Multivariate analysis revealed that cavity formation was an independent prognostic factor in adenocarcinoma (p = 0.028). Conclusions Cavitary adenocarcinoma has worse prognostic clinicopathologic characteristics than noncavitary adenocarcinoma. Based on this finding, cavitary and noncavitary adenocarcinoma tumors should be considered separate entities.

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