Abstract
We surveyed the prescriptions from the Department of Dermatology in a city hospital to determine the status of the use of admixtures of corticosteroid ointments with other ointments. Thirty percent of the prescriptions of topical ointment therapy for outpatients of the Department were for admixture ointments. They were prescribed for patients aged 2 months to over 90 years. The mixing ratios of corticosteroid ointments with other ointments were 1 : 1 to 5 : 3. One-to-one dilution was most frequently used. Corticosteroid ointments classified into strongest, very strong, strong and medium groups were used for admixtures. We studied the effect of admixture ointments on carrageenan-induced edema in rat hind paws to assess the anti-inflammatory activity of these admixtures. Dermovate™, its 1 : 3-diluted preparation with white petrolatum and 1 : 1-diluted preparation of Lidomex™ with white petrolatum exerted significant anti-inflammatory activity (p<0.05, compared with white petrolatum). These results suggest that the admixtures of different corticosteroid ointments have different anti-inflammatory activities. When admixture preparations are used, the properties of the corticosteroid and other ointments should be taken into account individually.
| Original language | English |
|---|---|
| Pages (from-to) | 93-97 |
| Number of pages | 5 |
| Journal | Yakugaku Zasshi |
| Volume | 124 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2004 Feb |
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Keywords
- Admixture
- Anti-inflammatory activity
- Carrageenan
- Corticosteroid ointment
- Survey
ASJC Scopus subject areas
- Molecular Medicine
Cite this
Survey of mixing commercially available corticosteroid ointments with other ointments and the anti-inflammatory activity of the admixtures. / Kizu, Junko; Ichihara, Wataru; Tomonaga, Eriko; Abe, Junko; Watanabe, Tomoko; Inoue, Tadao; Hori, Seiji.
In: Yakugaku Zasshi, Vol. 124, No. 2, 02.2004, p. 93-97.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Survey of mixing commercially available corticosteroid ointments with other ointments and the anti-inflammatory activity of the admixtures
AU - Kizu, Junko
AU - Ichihara, Wataru
AU - Tomonaga, Eriko
AU - Abe, Junko
AU - Watanabe, Tomoko
AU - Inoue, Tadao
AU - Hori, Seiji
PY - 2004/2
Y1 - 2004/2
N2 - We surveyed the prescriptions from the Department of Dermatology in a city hospital to determine the status of the use of admixtures of corticosteroid ointments with other ointments. Thirty percent of the prescriptions of topical ointment therapy for outpatients of the Department were for admixture ointments. They were prescribed for patients aged 2 months to over 90 years. The mixing ratios of corticosteroid ointments with other ointments were 1 : 1 to 5 : 3. One-to-one dilution was most frequently used. Corticosteroid ointments classified into strongest, very strong, strong and medium groups were used for admixtures. We studied the effect of admixture ointments on carrageenan-induced edema in rat hind paws to assess the anti-inflammatory activity of these admixtures. Dermovate™, its 1 : 3-diluted preparation with white petrolatum and 1 : 1-diluted preparation of Lidomex™ with white petrolatum exerted significant anti-inflammatory activity (p<0.05, compared with white petrolatum). These results suggest that the admixtures of different corticosteroid ointments have different anti-inflammatory activities. When admixture preparations are used, the properties of the corticosteroid and other ointments should be taken into account individually.
AB - We surveyed the prescriptions from the Department of Dermatology in a city hospital to determine the status of the use of admixtures of corticosteroid ointments with other ointments. Thirty percent of the prescriptions of topical ointment therapy for outpatients of the Department were for admixture ointments. They were prescribed for patients aged 2 months to over 90 years. The mixing ratios of corticosteroid ointments with other ointments were 1 : 1 to 5 : 3. One-to-one dilution was most frequently used. Corticosteroid ointments classified into strongest, very strong, strong and medium groups were used for admixtures. We studied the effect of admixture ointments on carrageenan-induced edema in rat hind paws to assess the anti-inflammatory activity of these admixtures. Dermovate™, its 1 : 3-diluted preparation with white petrolatum and 1 : 1-diluted preparation of Lidomex™ with white petrolatum exerted significant anti-inflammatory activity (p<0.05, compared with white petrolatum). These results suggest that the admixtures of different corticosteroid ointments have different anti-inflammatory activities. When admixture preparations are used, the properties of the corticosteroid and other ointments should be taken into account individually.
KW - Admixture
KW - Anti-inflammatory activity
KW - Carrageenan
KW - Corticosteroid ointment
KW - Survey
UR - http://www.scopus.com/inward/record.url?scp=1642297318&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1642297318&partnerID=8YFLogxK
U2 - 10.1248/yakushi.124.93
DO - 10.1248/yakushi.124.93
M3 - Article
C2 - 14978951
AN - SCOPUS:1642297318
VL - 124
SP - 93
EP - 97
JO - Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
JF - Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
SN - 0031-6903
IS - 2
ER -