Survey on once-daily therapy with ceftriaxone for pediatric bacterial infections

Satoshi Iwata, Hiromi Kumon, Yoshihito Niki, Nobuki Aoki, Mitsuo Kaku, Kouichi Wada, Shigeru Kohno, Keisuke Sunakawa, Hiroshige Mikamo, Yoshio Takesue, Naomasa Gotoh, Kouichi Monden

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Abstract

The use of antibacterial agents must have had a broad antibacterial spectrum and a strong antibacterial effect, and the medication plan of an antibacterial agent also considers pharmacokinetics in the treatment of bacterial infection. It is important to determine a medication interval based on "time above MIC" from a PK/PD in β-lactam antibacterial agents. Ceftriaxone(CTRX), an injectable cephem antibacterial agent, has a broad antibacterial spectrum and strong antibacterial effect, and showed sufficient antibacterial effect in once-daily treatment and that the half-life in blood is very long. The Japanese Society of Chemotherapy strongly desires the approval for a once-daily dosing regimen of CTRX. A survey on once-daily treatment with CTRX in pediatric bacterial infections yielded the following results. Some 51% of respondents (28/55 doctors) had used CTRX in once-daily treatment. The distribution of dosage and term were 50-59 mg/kg for 5 days in inpatients and 20-59 mg/kg for 3 days in outpatients. Advantages included outpatient use, administration without hospitalization equipment, maintenance of patient and family QOL and cutting of medical expenses after approval of once-daily CTRX treatment Dis- advantages included difficulty of the correspondence to the patients' emergency and the correspondence to adverse reactions of CTRX such as a drug allergy. The intentions to suppose that respondents want to use once-daily CTRX treatment were 80% for outpatients and 51% for inpatients respectively. We consider that sufficient information about advantages and disadvantages of once-daily CTRX treatment should be offered to physicians for an appropriate use of this regimen.

Original languageEnglish
Pages (from-to)463-472
Number of pages10
JournalJapanese Journal of Chemotherapy
Volume55
Issue number6
Publication statusPublished - 2007 Nov
Externally publishedYes

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Keywords

  • Bacterial infection
  • Ceftriaxone
  • Child
  • Once daily intravenous administration

ASJC Scopus subject areas

  • Pharmacology

Cite this

Iwata, S., Kumon, H., Niki, Y., Aoki, N., Kaku, M., Wada, K., Kohno, S., Sunakawa, K., Mikamo, H., Takesue, Y., Gotoh, N., & Monden, K. (2007). Survey on once-daily therapy with ceftriaxone for pediatric bacterial infections. Japanese Journal of Chemotherapy, 55(6), 463-472.