Survivin associates with cell proliferation in renal cancer cells: Regulation of survivin expression by insulin-like growth factor-1, interferon-γ and a novel NF-κB inhibitor

Akinori Sato, Mototsugu Oya, Keiichi Ito, Ryuichi Mizuno, Yutaka Horiguchi, Kazuo Umezawa, Masamichi Hayakawa, Masaru Murai

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Although survivin has been widely recognized as an attractive target for cancer therapy, the exact mechanism regarding the regulation of survivin and its effect on cell proliferation have yet to be clearly defined in renal cell carcinoma (RCC). We investigated herein the association between survivin expression and cell proliferation in a RCC cell line, KU19-20. In KU19-20 cells, cell proliferation and survivin expression were significantly induced by IGF-1, whereas they were inhibited by a novel NF-κB inhibitor dehydroxymethyl-epoxyquinomicin (DHMEQ) and IFN-γ. The combination of DHMEQ and IFN-γ inhibited cell proliferation synergistically with a pronounced attenuation of survivin expression. Furthermore, treatment with survivin-specific siRNA reduced expression of survivin and significantly inhibited cell proliferation. Survivin expression was thus associated with cell proliferation in KU19-20 cells. The regulation of survivin by IFN-γ and/or an NF-κB inhibitor may therefore be a potential treatment modality for RCC.

Original languageEnglish
Pages (from-to)841-846
Number of pages6
JournalInternational journal of oncology
Volume28
Issue number4
DOIs
Publication statusPublished - 2006 Apr

Keywords

  • Carcinoma
  • DHMEQ
  • Human
  • IFN-γ
  • IGF-1
  • Renal cell
  • Survivin protein

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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