Susceptibility of tenascin to degradation by matrix metalloproteinases and serine proteinases

Kazushi Imai, Moriaki Kusakabe, Teruyo Sakakura, Isao Nakanishi, Yasunori Okada

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

The degradation of tenascin purified from human melanoma cells was examined by treatment with matrix metalloproteinases (MMPs) and serine proteinases. Among eight different types of proteinases examined, MMP-1, -3, and -7, cathepsin G and leukocyte elastase could digest tenascin, but MMP-2, MMP-9 and thrombin did not. This suggests that tenascin may be readily catabolized by extracellular matrix-degrading proteinases found in the pathophysiological conditions.

Original languageEnglish
Pages (from-to)216-218
Number of pages3
JournalFEBS Letters
Volume352
Issue number2
DOIs
Publication statusPublished - 1994 Sep 26

Fingerprint

Tenascin
Serine Proteases
Matrix Metalloproteinases
Degradation
Peptide Hydrolases
Cathepsin G
Matrix Metalloproteinase 3
Leukocyte Elastase
Matrix Metalloproteinase 1
Matrix Metalloproteinase 2
Matrix Metalloproteinase 9
Thrombin
Extracellular Matrix
Melanoma

Keywords

  • Matrix metalloproteinase
  • Serine proteinase
  • Tenascin

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Susceptibility of tenascin to degradation by matrix metalloproteinases and serine proteinases. / Imai, Kazushi; Kusakabe, Moriaki; Sakakura, Teruyo; Nakanishi, Isao; Okada, Yasunori.

In: FEBS Letters, Vol. 352, No. 2, 26.09.1994, p. 216-218.

Research output: Contribution to journalArticle

Imai, K, Kusakabe, M, Sakakura, T, Nakanishi, I & Okada, Y 1994, 'Susceptibility of tenascin to degradation by matrix metalloproteinases and serine proteinases', FEBS Letters, vol. 352, no. 2, pp. 216-218. https://doi.org/10.1016/0014-5793(94)00960-0
Imai, Kazushi ; Kusakabe, Moriaki ; Sakakura, Teruyo ; Nakanishi, Isao ; Okada, Yasunori. / Susceptibility of tenascin to degradation by matrix metalloproteinases and serine proteinases. In: FEBS Letters. 1994 ; Vol. 352, No. 2. pp. 216-218.
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