Sustained subcutaneous infusion of nicotine enhances cholinergic vasodilation in the cerebral cortex induced by stimulation of the nucleus basalis of Meynert in rats

Sae Uchida, Harumi Hotta, Hidemi Misawa, Koichiro Kawashima

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The present study examined the effects of sustained nicotine exposure on the cholinergic vasodilative system originating in the nucleus basalis of Meynert (NBM) and projecting to the cerebral cortex in rats. Rats received sustained subcutaneous nicotine (100 μg/kg/h) for 14 days. Under urethane anesthesia, the vasodilation response and acetylcholine release in the parietal cortex induced by electrical stimulation of the NBM (10-200 μA) were measured. The basal level of acetylcholine release was significantly higher in nicotine-treated rats than in saline-treated control rats. In the control rats, both the acetylcholine release and blood flow were increased by NBM stimulation in a stimulus intensity-dependent manner, and a threshold of 50 μA. In nicotine-treated rats, the threshold intensity of NBM stimulation producing increases in acetylcholine release and blood flow was reduced to 20 μA. The stimulus intensity-dependent acetylcholine release and vasodilation by NBM stimulation were significantly larger in nicotine-treated rats than in control rats. We conclude that sustained subcutaneous infusion of nicotine enhances cholinergic vasodilative system in the cerebral cortex originating in the NBM.

Original languageEnglish
Pages (from-to)235-240
Number of pages6
JournalEuropean journal of pharmacology
Volume654
Issue number3
DOIs
Publication statusPublished - 2011 Mar 11

Keywords

  • (Rat)
  • Acetylcholine release
  • Cholinergic vasodilative fibers
  • Chronic nicotine
  • Cortical cerebral blood flow
  • Nucleus basalis of Meynert
  • Vasodilation

ASJC Scopus subject areas

  • Pharmacology

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