Symbiopolyol, a VCAM-1 inhibitor from a symbiotic dinoflagellate of the jellyfish mastigias papua

Novriyandi Hanif, Osamu Ohno, Makoto Kitamura, Kaoru Yamada, Daisuke Uemura

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

A super-carbon-chain compound, symbiopolyol (1a), was isolated from a symbiotic dinoflagellate of the jellyfish Mastigias papua. Although a direct comparison between symbiopolyol (1a) and lingshuiol B has not been completed, symbiopolyol (1a) is suggested to be the enantiomer of lingshuiol B. The structure of 1a, including its partial relative configuration, was elucidated on the basis of interpretation of spectroscopic data and chemical transformations. This compound exhibited significant inhibitory activity against the expression of VCAM-1 in human umbilical vein endothelial cells (HUVEC).

Original languageEnglish
Pages (from-to)1318-1322
Number of pages5
JournalJournal of Natural Products
Volume73
Issue number7
DOIs
Publication statusPublished - 2010 Jul 23

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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