Symbiopolyol, a VCAM-1 inhibitor from a symbiotic dinoflagellate of the jellyfish mastigias papua

Novriyandi Hanif; Osamu Ohno; Makoto Kitamura; Kaoru Yamada; Daisuke Uemura

doi:10.1021/np100221k

Symbiopolyol, a VCAM-1 inhibitor from a symbiotic dinoflagellate of the jellyfish mastigias papua

Novriyandi Hanif, Osamu Ohno, Makoto Kitamura, Kaoru Yamada, Daisuke Uemura

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

A super-carbon-chain compound, symbiopolyol (1a), was isolated from a symbiotic dinoflagellate of the jellyfish Mastigias papua. Although a direct comparison between symbiopolyol (1a) and lingshuiol B has not been completed, symbiopolyol (1a) is suggested to be the enantiomer of lingshuiol B. The structure of 1a, including its partial relative configuration, was elucidated on the basis of interpretation of spectroscopic data and chemical transformations. This compound exhibited significant inhibitory activity against the expression of VCAM-1 in human umbilical vein endothelial cells (HUVEC).

Original language	English
Pages (from-to)	1318-1322
Number of pages	5
Journal	Journal of Natural Products
Volume	73
Issue number	7
DOIs	https://doi.org/10.1021/np100221k
Publication status	Published - 2010 Jul 23
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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AU - Ohno, Osamu

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AU - Yamada, Kaoru

AU - Uemura, Daisuke

PY - 2010/7/23

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AB - A super-carbon-chain compound, symbiopolyol (1a), was isolated from a symbiotic dinoflagellate of the jellyfish Mastigias papua. Although a direct comparison between symbiopolyol (1a) and lingshuiol B has not been completed, symbiopolyol (1a) is suggested to be the enantiomer of lingshuiol B. The structure of 1a, including its partial relative configuration, was elucidated on the basis of interpretation of spectroscopic data and chemical transformations. This compound exhibited significant inhibitory activity against the expression of VCAM-1 in human umbilical vein endothelial cells (HUVEC).

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Symbiopolyol, a VCAM-1 inhibitor from a symbiotic dinoflagellate of the jellyfish mastigias papua

Abstract

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