Synapse formation and maintenance by C1q family proteins: A new class of secreted synapse organizers

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27 Citations (Scopus)

Abstract

Several C1q family members, especially the Cbln and C1q-like subfamilies, are highly and predominantly expressed in the central nervous system. Cbln1, a member of the Cbln subfamily, plays two unique roles at parallel ber (PF)-Purkinje cell synapses in the cerebellum: the formation and stabilization of synaptic contact, and the control of functional synaptic plasticity by regulating the postsynaptic endocytotic pathway. The delta2 glutamate receptor (GluD2), which is predominantly expressed in Purkinje cells, plays similar critical roles in the cerebellum. In addition, viral expression of GluD2 or the application of recombinant Cbln1 induces PF- Purkinje cell synaptogenesis in vitro and in vivo. Antigen-unmasking methods were necessary to reveal the immunoreactivities for endogenous Cbln1 and GluD2 at the synaptic junction of PF synapses. We propose that Cbln1 and GluD2 are located at the synaptic cleft, where various proteins undergo intricate molecular interactions with each other, and serve as a bidirectional synaptic organizer.

Original languageEnglish
Pages (from-to)191-197
Number of pages7
JournalEuropean Journal of Neuroscience
Volume32
Issue number2
DOIs
Publication statusPublished - 2010 Jul

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Purkinje Cells
Staphylococcal Protein A
Synapses
Maintenance
Cerebellum
Neuronal Plasticity
Central Nervous System
Antigens
Proteins

Keywords

  • Cerebellum
  • Ltd
  • Mouse
  • Purkinje cell
  • Synaptogenesis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

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title = "Synapse formation and maintenance by C1q family proteins: A new class of secreted synapse organizers",
abstract = "Several C1q family members, especially the Cbln and C1q-like subfamilies, are highly and predominantly expressed in the central nervous system. Cbln1, a member of the Cbln subfamily, plays two unique roles at parallel ber (PF)-Purkinje cell synapses in the cerebellum: the formation and stabilization of synaptic contact, and the control of functional synaptic plasticity by regulating the postsynaptic endocytotic pathway. The delta2 glutamate receptor (GluD2), which is predominantly expressed in Purkinje cells, plays similar critical roles in the cerebellum. In addition, viral expression of GluD2 or the application of recombinant Cbln1 induces PF- Purkinje cell synaptogenesis in vitro and in vivo. Antigen-unmasking methods were necessary to reveal the immunoreactivities for endogenous Cbln1 and GluD2 at the synaptic junction of PF synapses. We propose that Cbln1 and GluD2 are located at the synaptic cleft, where various proteins undergo intricate molecular interactions with each other, and serve as a bidirectional synaptic organizer.",
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