Synaptically activated Ca2+ release from internal stores in CNS neurons

William N. Ross, Takeshi Nakamura, Shigeo Watanabe, Matthew Larkum, Nechama Lasser-Ross

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

1. Synaptically activated postsynaptic [Ca2+] i increases occur through three main pathways: Ca2+ entry through voltage-gated Ca2+ channels, Ca2+ entry through ligand-gated channels, and Ca2+ release from internal stores. The first two pathways have been studied intensively; release from stores has been the subject of more recent investigations. 2. Ca2+ release from stores in CNS neurons primarily occurs as a result of IP3 mobilized by activation of metabotropic glutamatergic and/or cholingergic receptors coupled to PLC. Ca2+ release is localized near spines in Purkinje cells and occurs as a wave in the primary apical dendrites of pyramidal cells in the hippocampus and cortex. The amplitude of the [Ca2+]i increase can reach several micromolar, significantly larger than the increase due to backpropagating spikes. 3. The large amplitude, long duration, and unique location of the [Ca2+]i increases due to Ca2+ release from stores suggests that these increases can affect specific downstream signaling mechanisms in neurons.

Original languageEnglish
Pages (from-to)283-295
Number of pages13
JournalCellular and Molecular Neurobiology
Volume25
Issue number2
DOIs
Publication statusPublished - 2005 Apr
Externally publishedYes

Keywords

  • Calcium
  • Dendrite
  • IP
  • Pyramidal neuron

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Biochemistry
  • Cell Biology
  • Genetics

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  • Cite this

    Ross, W. N., Nakamura, T., Watanabe, S., Larkum, M., & Lasser-Ross, N. (2005). Synaptically activated Ca2+ release from internal stores in CNS neurons. Cellular and Molecular Neurobiology, 25(2), 283-295. https://doi.org/10.1007/s10571-005-3060-0