Synchronous male bladder cancer and breast cancer - a case report

Nobushige Yabe, Shinji Murai, Chikara Kunugi, Jyunpei Nakadai, Ippei Oto, Takahisa Yoshikawa, Kenjiro Kitasato, Hirotomo Shimizu, Akihiko Nakamura, Aya Masuda, Yasumasa Miyazaki, Masakazu Ohashi, Hiromitsu Jinno, Yuukou Kitagawa

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Abstract

A 74-year-old man complained of blood in his urine over a 1-week period beginning in early October 2013, and was examined in the urology department of our hospital. A thorough examination revealed bladder cancer, and surgery was planned after two cycles of preoperative gemcitabine plus cisplatin chemotherapy. A chest computed tomography (CT) performed to evaluate the response to chemotherapy revealed a mass in the right breast. The patient had previously complained about the same site, and mammography and ultrasonography had suggested the possibility of a malignant mammary gland tumor. The results of aspiration cytology were Class V, and based on that finding, a diagnosis of cancer of the right breast was made. In February 2014, we performed a mastectomy, while preserving the pectoral muscles, along with sentinel node biopsy, total cystectomy, urethrectomy, pelvic lymph node dissection, and ureteroileal anastomosis. The histopathological diagnosis of the right breast tumor was invasive ductal carcinoma[scirrhous carcinoma, ly (+), v (-), g (+), f (+), s (+), nuclear grade 1=atypia 2+mitosis 1, EIC (-), ICT (-), NCAT (-)]. A micrometastatic tumor measuring approximately 1mm was observed in the sentinel lymph node. The breast disease was classified as pT1N1mi(sn)M0, Stage IIA, and the tumor was ER (+), PgR (+), HER2/neu (2+), and FISH (-). The bladder cancer was diagnosed as urothelial carcinoma, non-papillary, invasive G2>G3, pT2a; no pelvic lymph node metastases were detected, and it was classified as pT2aN0M0, Stage II. Synchronous male breast cancer and bladder cancer is a very rare condition, and we report the case with a review of the literature.

Original languageEnglish
Pages (from-to)1978-1980
Number of pages3
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume41
Issue number12
Publication statusPublished - 2014 Nov 1

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Urinary Bladder Neoplasms
Breast Neoplasms
gemcitabine
Hospital Urology Department
Scirrhous Adenocarcinoma
Male Breast Neoplasms
Pectoralis Muscles
Drug Therapy
Ductal Carcinoma
Breast Diseases
Papillary Carcinoma
Cystectomy
Mastectomy
Mammography
Human Mammary Glands
Lymph Node Excision
Mitosis
Cisplatin
Cell Biology
Ultrasonography

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Yabe, N., Murai, S., Kunugi, C., Nakadai, J., Oto, I., Yoshikawa, T., ... Kitagawa, Y. (2014). Synchronous male bladder cancer and breast cancer - a case report. Gan to kagaku ryoho. Cancer & chemotherapy, 41(12), 1978-1980.

Synchronous male bladder cancer and breast cancer - a case report. / Yabe, Nobushige; Murai, Shinji; Kunugi, Chikara; Nakadai, Jyunpei; Oto, Ippei; Yoshikawa, Takahisa; Kitasato, Kenjiro; Shimizu, Hirotomo; Nakamura, Akihiko; Masuda, Aya; Miyazaki, Yasumasa; Ohashi, Masakazu; Jinno, Hiromitsu; Kitagawa, Yuukou.

In: Gan to kagaku ryoho. Cancer & chemotherapy, Vol. 41, No. 12, 01.11.2014, p. 1978-1980.

Research output: Contribution to journalArticle

Yabe, N, Murai, S, Kunugi, C, Nakadai, J, Oto, I, Yoshikawa, T, Kitasato, K, Shimizu, H, Nakamura, A, Masuda, A, Miyazaki, Y, Ohashi, M, Jinno, H & Kitagawa, Y 2014, 'Synchronous male bladder cancer and breast cancer - a case report', Gan to kagaku ryoho. Cancer & chemotherapy, vol. 41, no. 12, pp. 1978-1980.
Yabe N, Murai S, Kunugi C, Nakadai J, Oto I, Yoshikawa T et al. Synchronous male bladder cancer and breast cancer - a case report. Gan to kagaku ryoho. Cancer & chemotherapy. 2014 Nov 1;41(12):1978-1980.
Yabe, Nobushige ; Murai, Shinji ; Kunugi, Chikara ; Nakadai, Jyunpei ; Oto, Ippei ; Yoshikawa, Takahisa ; Kitasato, Kenjiro ; Shimizu, Hirotomo ; Nakamura, Akihiko ; Masuda, Aya ; Miyazaki, Yasumasa ; Ohashi, Masakazu ; Jinno, Hiromitsu ; Kitagawa, Yuukou. / Synchronous male bladder cancer and breast cancer - a case report. In: Gan to kagaku ryoho. Cancer & chemotherapy. 2014 ; Vol. 41, No. 12. pp. 1978-1980.
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AU - Yoshikawa, Takahisa

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AU - Masuda, Aya

AU - Miyazaki, Yasumasa

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N2 - A 74-year-old man complained of blood in his urine over a 1-week period beginning in early October 2013, and was examined in the urology department of our hospital. A thorough examination revealed bladder cancer, and surgery was planned after two cycles of preoperative gemcitabine plus cisplatin chemotherapy. A chest computed tomography (CT) performed to evaluate the response to chemotherapy revealed a mass in the right breast. The patient had previously complained about the same site, and mammography and ultrasonography had suggested the possibility of a malignant mammary gland tumor. The results of aspiration cytology were Class V, and based on that finding, a diagnosis of cancer of the right breast was made. In February 2014, we performed a mastectomy, while preserving the pectoral muscles, along with sentinel node biopsy, total cystectomy, urethrectomy, pelvic lymph node dissection, and ureteroileal anastomosis. The histopathological diagnosis of the right breast tumor was invasive ductal carcinoma[scirrhous carcinoma, ly (+), v (-), g (+), f (+), s (+), nuclear grade 1=atypia 2+mitosis 1, EIC (-), ICT (-), NCAT (-)]. A micrometastatic tumor measuring approximately 1mm was observed in the sentinel lymph node. The breast disease was classified as pT1N1mi(sn)M0, Stage IIA, and the tumor was ER (+), PgR (+), HER2/neu (2+), and FISH (-). The bladder cancer was diagnosed as urothelial carcinoma, non-papillary, invasive G2>G3, pT2a; no pelvic lymph node metastases were detected, and it was classified as pT2aN0M0, Stage II. Synchronous male breast cancer and bladder cancer is a very rare condition, and we report the case with a review of the literature.

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