Syndrome of inappropriate secretion of antidiuretic hormone after chemotherapy with vinorelbine

Hiroaki Kuroda; Masafumi Kawamura; Tai Hato; Kazunori Kamiya; Masahiro Kawakubo; Yotaro Izumi; Masazumi Watanabe; Hirohisa Horinouchi; Koichi Kobayashi

doi:10.1007/s00280-007-0636-z

Syndrome of inappropriate secretion of antidiuretic hormone after chemotherapy with vinorelbine

Hiroaki Kuroda, Masafumi Kawamura, Tai Hato, Kazunori Kamiya, Masahiro Kawakubo, Yotaro Izumi, Masazumi Watanabe, Hirohisa Horinouchi, Koichi Kobayashi

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Purpose: To describe a case of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) after administration of vinorelbine (VNB) for recurrence of lung cancer. Case: A 76-year-old man underwent bronchial arterial infusion (BAI) of VNB for postoperative recurrence of lung cancer. Seven days later, hyponatremia and natriuresis developed. Based on his clinical and laboratory findings, we diagnosed him with SIADH. He improved within a couple of days with fluid restriction only. Conclusions: Administration of VNB may potentially cause SIADH. This is the second report of the SIADH caused by VNB. It is important to monitor the serum sodium level and clinical findings after chemotherapy with VNB.

Original language	English
Pages (from-to)	331-333
Number of pages	3
Journal	Cancer Chemotherapy and Pharmacology
Volume	62
Issue number	2
DOIs	https://doi.org/10.1007/s00280-007-0636-z
Publication status	Published - 2008 Jul
Externally published	Yes

Keywords

Chemotherapy
Non-small cell lung cancer
Syndrome of inappropriate secretion of antidiuretic hormone (SIADH)
Vinorelbine (VNB)

ASJC Scopus subject areas

Oncology
Toxicology
Pharmacology
Cancer Research
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00280-007-0636-z

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Syndrome of inappropriate secretion of antidiuretic hormone after chemotherapy with vinorelbine. / Kuroda, Hiroaki; Kawamura, Masafumi; Hato, Tai; Kamiya, Kazunori; Kawakubo, Masahiro; Izumi, Yotaro; Watanabe, Masazumi; Horinouchi, Hirohisa; Kobayashi, Koichi.

In: Cancer Chemotherapy and Pharmacology, Vol. 62, No. 2, 07.2008, p. 331-333.

Research output: Contribution to journal › Article › peer-review

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abstract = "Purpose: To describe a case of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) after administration of vinorelbine (VNB) for recurrence of lung cancer. Case: A 76-year-old man underwent bronchial arterial infusion (BAI) of VNB for postoperative recurrence of lung cancer. Seven days later, hyponatremia and natriuresis developed. Based on his clinical and laboratory findings, we diagnosed him with SIADH. He improved within a couple of days with fluid restriction only. Conclusions: Administration of VNB may potentially cause SIADH. This is the second report of the SIADH caused by VNB. It is important to monitor the serum sodium level and clinical findings after chemotherapy with VNB.",

keywords = "Chemotherapy, Non-small cell lung cancer, Syndrome of inappropriate secretion of antidiuretic hormone (SIADH), Vinorelbine (VNB)",

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AU - Kuroda, Hiroaki

AU - Kawamura, Masafumi

AU - Hato, Tai

AU - Kamiya, Kazunori

AU - Kawakubo, Masahiro

AU - Izumi, Yotaro

AU - Watanabe, Masazumi

AU - Horinouchi, Hirohisa

AU - Kobayashi, Koichi

PY - 2008/7

Y1 - 2008/7

N2 - Purpose: To describe a case of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) after administration of vinorelbine (VNB) for recurrence of lung cancer. Case: A 76-year-old man underwent bronchial arterial infusion (BAI) of VNB for postoperative recurrence of lung cancer. Seven days later, hyponatremia and natriuresis developed. Based on his clinical and laboratory findings, we diagnosed him with SIADH. He improved within a couple of days with fluid restriction only. Conclusions: Administration of VNB may potentially cause SIADH. This is the second report of the SIADH caused by VNB. It is important to monitor the serum sodium level and clinical findings after chemotherapy with VNB.

AB - Purpose: To describe a case of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) after administration of vinorelbine (VNB) for recurrence of lung cancer. Case: A 76-year-old man underwent bronchial arterial infusion (BAI) of VNB for postoperative recurrence of lung cancer. Seven days later, hyponatremia and natriuresis developed. Based on his clinical and laboratory findings, we diagnosed him with SIADH. He improved within a couple of days with fluid restriction only. Conclusions: Administration of VNB may potentially cause SIADH. This is the second report of the SIADH caused by VNB. It is important to monitor the serum sodium level and clinical findings after chemotherapy with VNB.

KW - Chemotherapy

KW - Non-small cell lung cancer

KW - Syndrome of inappropriate secretion of antidiuretic hormone (SIADH)

KW - Vinorelbine (VNB)

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Syndrome of inappropriate secretion of antidiuretic hormone after chemotherapy with vinorelbine

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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