Abstract
Purpose: To describe a case of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) after administration of vinorelbine (VNB) for recurrence of lung cancer. Case: A 76-year-old man underwent bronchial arterial infusion (BAI) of VNB for postoperative recurrence of lung cancer. Seven days later, hyponatremia and natriuresis developed. Based on his clinical and laboratory findings, we diagnosed him with SIADH. He improved within a couple of days with fluid restriction only. Conclusions: Administration of VNB may potentially cause SIADH. This is the second report of the SIADH caused by VNB. It is important to monitor the serum sodium level and clinical findings after chemotherapy with VNB.
| Original language | English |
|---|---|
| Pages (from-to) | 331-333 |
| Number of pages | 3 |
| Journal | Cancer Chemotherapy and Pharmacology |
| Volume | 62 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2008 Jul |
Keywords
- Chemotherapy
- Non-small cell lung cancer
- Syndrome of inappropriate secretion of antidiuretic hormone (SIADH)
- Vinorelbine (VNB)
ASJC Scopus subject areas
- Oncology
- Toxicology
- Pharmacology
- Cancer Research
- Pharmacology (medical)
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Cite this
Kuroda, H., Kawamura, M., Hato, T., Kamiya, K., Kawakubo, M., Izumi, Y., Watanabe, M., Horinouchi, H., & Kobayashi, K. (2008). Syndrome of inappropriate secretion of antidiuretic hormone after chemotherapy with vinorelbine. Cancer Chemotherapy and Pharmacology, 62(2), 331-333. https://doi.org/10.1007/s00280-007-0636-z