TY - JOUR
T1 - Syndrome of inappropriate secretion of antidiuretic hormone after chemotherapy with vinorelbine
AU - Kuroda, Hiroaki
AU - Kawamura, Masafumi
AU - Hato, Tai
AU - Kamiya, Kazunori
AU - Kawakubo, Masahiro
AU - Izumi, Yotaro
AU - Watanabe, Masazumi
AU - Horinouchi, Hirohisa
AU - Kobayashi, Koichi
PY - 2008/7
Y1 - 2008/7
N2 - Purpose: To describe a case of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) after administration of vinorelbine (VNB) for recurrence of lung cancer. Case: A 76-year-old man underwent bronchial arterial infusion (BAI) of VNB for postoperative recurrence of lung cancer. Seven days later, hyponatremia and natriuresis developed. Based on his clinical and laboratory findings, we diagnosed him with SIADH. He improved within a couple of days with fluid restriction only. Conclusions: Administration of VNB may potentially cause SIADH. This is the second report of the SIADH caused by VNB. It is important to monitor the serum sodium level and clinical findings after chemotherapy with VNB.
AB - Purpose: To describe a case of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) after administration of vinorelbine (VNB) for recurrence of lung cancer. Case: A 76-year-old man underwent bronchial arterial infusion (BAI) of VNB for postoperative recurrence of lung cancer. Seven days later, hyponatremia and natriuresis developed. Based on his clinical and laboratory findings, we diagnosed him with SIADH. He improved within a couple of days with fluid restriction only. Conclusions: Administration of VNB may potentially cause SIADH. This is the second report of the SIADH caused by VNB. It is important to monitor the serum sodium level and clinical findings after chemotherapy with VNB.
KW - Chemotherapy
KW - Non-small cell lung cancer
KW - Syndrome of inappropriate secretion of antidiuretic hormone (SIADH)
KW - Vinorelbine (VNB)
UR - http://www.scopus.com/inward/record.url?scp=43749121677&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=43749121677&partnerID=8YFLogxK
U2 - 10.1007/s00280-007-0636-z
DO - 10.1007/s00280-007-0636-z
M3 - Article
C2 - 17989977
AN - SCOPUS:43749121677
VL - 62
SP - 331
EP - 333
JO - Cancer Chemotherapy and Pharmacology
JF - Cancer Chemotherapy and Pharmacology
SN - 0344-5704
IS - 2
ER -
