Syndrome of inappropriate secretion of antidiuretic hormone after chemotherapy with vinorelbine

Hiroaki Kuroda; Masafumi Kawamura; Tai Hato; Kazunori Kamiya; Masahiro Kawakubo; Yotaro Izumi; Masazumi Watanabe; Hirohisa Horinouchi; Koichi Kobayashi

doi:10.1007/s00280-007-0636-z

Syndrome of inappropriate secretion of antidiuretic hormone after chemotherapy with vinorelbine

Hiroaki Kuroda, Masafumi Kawamura, Tai Hato, Kazunori Kamiya, Masahiro Kawakubo, Yotaro Izumi, Masazumi Watanabe, Hirohisa Horinouchi, Koichi Kobayashi

School of Medicine

Research output: Contribution to journal › Article

11 Citations (Scopus)

Abstract

Purpose: To describe a case of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) after administration of vinorelbine (VNB) for recurrence of lung cancer. Case: A 76-year-old man underwent bronchial arterial infusion (BAI) of VNB for postoperative recurrence of lung cancer. Seven days later, hyponatremia and natriuresis developed. Based on his clinical and laboratory findings, we diagnosed him with SIADH. He improved within a couple of days with fluid restriction only. Conclusions: Administration of VNB may potentially cause SIADH. This is the second report of the SIADH caused by VNB. It is important to monitor the serum sodium level and clinical findings after chemotherapy with VNB.

Original language	English
Pages (from-to)	331-333
Number of pages	3
Journal	Cancer Chemotherapy and Pharmacology
Volume	62
Issue number	2
DOIs	https://doi.org/10.1007/s00280-007-0636-z
Publication status	Published - 2008 Jul

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Keywords

Chemotherapy
Non-small cell lung cancer
Syndrome of inappropriate secretion of antidiuretic hormone (SIADH)
Vinorelbine (VNB)

ASJC Scopus subject areas

Oncology
Toxicology
Pharmacology
Cancer Research
Pharmacology (medical)

Cite this

Kuroda, H., Kawamura, M., Hato, T., Kamiya, K., Kawakubo, M., Izumi, Y., Watanabe, M., Horinouchi, H., & Kobayashi, K. (2008). Syndrome of inappropriate secretion of antidiuretic hormone after chemotherapy with vinorelbine. Cancer Chemotherapy and Pharmacology, 62(2), 331-333. https://doi.org/10.1007/s00280-007-0636-z

Syndrome of inappropriate secretion of antidiuretic hormone after chemotherapy with vinorelbine. / Kuroda, Hiroaki; Kawamura, Masafumi; Hato, Tai; Kamiya, Kazunori; Kawakubo, Masahiro; Izumi, Yotaro; Watanabe, Masazumi; Horinouchi, Hirohisa; Kobayashi, Koichi.

In: Cancer Chemotherapy and Pharmacology, Vol. 62, No. 2, 07.2008, p. 331-333.

Research output: Contribution to journal › Article

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10.1007/s00280-007-0636-z