Synergistic antitumor activity of mitomycin C and cisplatin against gastric cancer cells in vitro

Yoshiro Saikawa, Tetsuro Kubota, Tsong‐Hong ‐H Kuo, Suguru Kase, Toshiharu Furukawa, Hirokazu Tanino, Kyuya Ishibiki, Masaki Kitajima

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The synergistic antitumor activity of mitomycin C (MMC) and cisplatin (DDP) against the gastric cancer cell lines MKN‐28 and MKN‐45 was assessed in vitro using the MTT assay. The synergism of the two agents was evaluated in terms of the interaction index (I.I.). The sequence of MMC followed by DDP showed higher antitumor activity than the reverse sequence against MKN‐28 and MKN‐45, and the intracellular concentration of platinum was significantly increased in MKN‐45 by preincubation with MMC, suggesting that MMC modulates cellular permeability to DDP or the ability of DDP to intercalate DNA. Since these two antitumor agents show different types of toxicity clinically, i.e., myelotoxicity by MMC and nephrotoxicity by DDP, this combination chemotherapy could be advantageous by providing synergistic antitumor activity without increased toxicity. © 1993 Wiley‐Liss, Inc.

Original languageEnglish
Pages (from-to)98-102
Number of pages5
JournalJournal of Surgical Oncology
Volume54
Issue number2
DOIs
Publication statusPublished - 1993 Oct

Keywords

  • biochemical modulation
  • combination chemotherapy
  • gastric cancer

ASJC Scopus subject areas

  • Surgery
  • Oncology

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