Synergistic effect of combined treatment with gamma-tocotrienol and statin on human malignant mesothelioma cells

Guligena Tuerdi, Saki Ichinomiya, Hiromi Sato, Sana Siddig, Eriko Suwa, Hiroki Iwata, Tomohiro Yano, Koichi Ueno

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The present study is the first to demonstrate the synergetic effect of statins (atorvastatin and simvastatin) and gamma-tocotrienol (γ-T3) on human malignant mesothelioma (MM). Statin + γ-T3 combinations induced greater cell growth inhibition more than each single treatment via inhibition of mevalonate pathway, a well-known target of both γ-T3 and statins. γ-T3 was necessary for endoplasmic reticulum stress markers CHOP and GRP78, whereas an intrinsic apoptotic marker, caspase 3 activation was induced only in the presence of statins. Overall, the combination of γ-T3 and statins could be useful for MM therapy and functions in a complementary style.

Original languageEnglish
Pages (from-to)116-127
Number of pages12
JournalCancer Letters
Volume339
Issue number1
DOIs
Publication statusPublished - 2013 Oct 1
Externally publishedYes

Fingerprint

Simvastatin
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Mevalonic Acid
Endoplasmic Reticulum Stress
Caspase 3
plastochromanol 8
Atorvastatin Calcium
Malignant Mesothelioma
Growth
Therapeutics

Keywords

  • Apoptosis
  • Gamma tocotrienol
  • Mesothelioma
  • Mevalonate pathway
  • Statin

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Synergistic effect of combined treatment with gamma-tocotrienol and statin on human malignant mesothelioma cells. / Tuerdi, Guligena; Ichinomiya, Saki; Sato, Hiromi; Siddig, Sana; Suwa, Eriko; Iwata, Hiroki; Yano, Tomohiro; Ueno, Koichi.

In: Cancer Letters, Vol. 339, No. 1, 01.10.2013, p. 116-127.

Research output: Contribution to journalArticle

Tuerdi, Guligena ; Ichinomiya, Saki ; Sato, Hiromi ; Siddig, Sana ; Suwa, Eriko ; Iwata, Hiroki ; Yano, Tomohiro ; Ueno, Koichi. / Synergistic effect of combined treatment with gamma-tocotrienol and statin on human malignant mesothelioma cells. In: Cancer Letters. 2013 ; Vol. 339, No. 1. pp. 116-127.
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AU - Suwa, Eriko

AU - Iwata, Hiroki

AU - Yano, Tomohiro

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