Synergistic effect of combined treatment with gamma-tocotrienol and statin on human malignant mesothelioma cells

Guligena Tuerdi, Saki Ichinomiya, Hiromi Sato, Sana Siddig, Eriko Suwa, Hiroki Iwata, Tomohiro Yano, Koichi Ueno

Research output: Contribution to journalArticle

12 Citations (Scopus)


The present study is the first to demonstrate the synergetic effect of statins (atorvastatin and simvastatin) and gamma-tocotrienol (γ-T3) on human malignant mesothelioma (MM). Statin + γ-T3 combinations induced greater cell growth inhibition more than each single treatment via inhibition of mevalonate pathway, a well-known target of both γ-T3 and statins. γ-T3 was necessary for endoplasmic reticulum stress markers CHOP and GRP78, whereas an intrinsic apoptotic marker, caspase 3 activation was induced only in the presence of statins. Overall, the combination of γ-T3 and statins could be useful for MM therapy and functions in a complementary style.

Original languageEnglish
Pages (from-to)116-127
Number of pages12
JournalCancer Letters
Issue number1
Publication statusPublished - 2013 Oct 1
Externally publishedYes



  • Apoptosis
  • Gamma tocotrienol
  • Mesothelioma
  • Mevalonate pathway
  • Statin

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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