Synergistic induction of astrocytic differentiation by factors secreted from meninges in the mouse developing brain

Yoichiro Kawamura, Sayako Katada, Hirofumi Noguchi, Hiroyuki Yamamoto, Tsukasa Sanosaka, Koji Iihara, Kinichi Nakashima

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Astrocytes, which support diverse neuronal functions, are generated from multipotent neural stem/precursor cells (NS/PCs) during brain development. Although many astrocyte-inducing factors have been identified and studied in vitro, the regions and/or cells that produce these factors in the developing brain remain elusive. Here, we show that meninges-produced factors induce astrocytic differentiation of NS/PCs. Consistent with the timing when astrocytic differentiation of NS/PCs increases, expression of astrocyte-inducing factors is upregulated. Meningeal secretion-mimicking combinatorial treatment of NS/PCs with bone morphogenetic protein 4, retinoic acid and leukemia inhibitory factor synergistically activate the promoter of a typical astrocytic marker, glial fibrillary acidic protein. Taken together, our data suggest that meninges play an important role in astrocytic differentiation of NS/PCs in the developing brain.

Original languageEnglish
JournalFEBS Letters
DOIs
Publication statusAccepted/In press - 2017
Externally publishedYes

Fingerprint

Meninges
Neural Stem Cells
Brain
Astrocytes
Bone Morphogenetic Protein 4
Leukemia Inhibitory Factor
Glial Fibrillary Acidic Protein
Multipotent Stem Cells
Tretinoin

Keywords

  • Astrocyte differentiation
  • Meninges
  • Neural stem/precursor cells

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Synergistic induction of astrocytic differentiation by factors secreted from meninges in the mouse developing brain. / Kawamura, Yoichiro; Katada, Sayako; Noguchi, Hirofumi; Yamamoto, Hiroyuki; Sanosaka, Tsukasa; Iihara, Koji; Nakashima, Kinichi.

In: FEBS Letters, 2017.

Research output: Contribution to journalArticle

Kawamura, Yoichiro ; Katada, Sayako ; Noguchi, Hirofumi ; Yamamoto, Hiroyuki ; Sanosaka, Tsukasa ; Iihara, Koji ; Nakashima, Kinichi. / Synergistic induction of astrocytic differentiation by factors secreted from meninges in the mouse developing brain. In: FEBS Letters. 2017.
@article{5ee387c46d6747db86b908f426dd7777,
title = "Synergistic induction of astrocytic differentiation by factors secreted from meninges in the mouse developing brain",
abstract = "Astrocytes, which support diverse neuronal functions, are generated from multipotent neural stem/precursor cells (NS/PCs) during brain development. Although many astrocyte-inducing factors have been identified and studied in vitro, the regions and/or cells that produce these factors in the developing brain remain elusive. Here, we show that meninges-produced factors induce astrocytic differentiation of NS/PCs. Consistent with the timing when astrocytic differentiation of NS/PCs increases, expression of astrocyte-inducing factors is upregulated. Meningeal secretion-mimicking combinatorial treatment of NS/PCs with bone morphogenetic protein 4, retinoic acid and leukemia inhibitory factor synergistically activate the promoter of a typical astrocytic marker, glial fibrillary acidic protein. Taken together, our data suggest that meninges play an important role in astrocytic differentiation of NS/PCs in the developing brain.",
keywords = "Astrocyte differentiation, Meninges, Neural stem/precursor cells",
author = "Yoichiro Kawamura and Sayako Katada and Hirofumi Noguchi and Hiroyuki Yamamoto and Tsukasa Sanosaka and Koji Iihara and Kinichi Nakashima",
year = "2017",
doi = "10.1002/1873-3468.12881",
language = "English",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",

}

TY - JOUR

T1 - Synergistic induction of astrocytic differentiation by factors secreted from meninges in the mouse developing brain

AU - Kawamura, Yoichiro

AU - Katada, Sayako

AU - Noguchi, Hirofumi

AU - Yamamoto, Hiroyuki

AU - Sanosaka, Tsukasa

AU - Iihara, Koji

AU - Nakashima, Kinichi

PY - 2017

Y1 - 2017

N2 - Astrocytes, which support diverse neuronal functions, are generated from multipotent neural stem/precursor cells (NS/PCs) during brain development. Although many astrocyte-inducing factors have been identified and studied in vitro, the regions and/or cells that produce these factors in the developing brain remain elusive. Here, we show that meninges-produced factors induce astrocytic differentiation of NS/PCs. Consistent with the timing when astrocytic differentiation of NS/PCs increases, expression of astrocyte-inducing factors is upregulated. Meningeal secretion-mimicking combinatorial treatment of NS/PCs with bone morphogenetic protein 4, retinoic acid and leukemia inhibitory factor synergistically activate the promoter of a typical astrocytic marker, glial fibrillary acidic protein. Taken together, our data suggest that meninges play an important role in astrocytic differentiation of NS/PCs in the developing brain.

AB - Astrocytes, which support diverse neuronal functions, are generated from multipotent neural stem/precursor cells (NS/PCs) during brain development. Although many astrocyte-inducing factors have been identified and studied in vitro, the regions and/or cells that produce these factors in the developing brain remain elusive. Here, we show that meninges-produced factors induce astrocytic differentiation of NS/PCs. Consistent with the timing when astrocytic differentiation of NS/PCs increases, expression of astrocyte-inducing factors is upregulated. Meningeal secretion-mimicking combinatorial treatment of NS/PCs with bone morphogenetic protein 4, retinoic acid and leukemia inhibitory factor synergistically activate the promoter of a typical astrocytic marker, glial fibrillary acidic protein. Taken together, our data suggest that meninges play an important role in astrocytic differentiation of NS/PCs in the developing brain.

KW - Astrocyte differentiation

KW - Meninges

KW - Neural stem/precursor cells

UR - http://www.scopus.com/inward/record.url?scp=85033217630&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85033217630&partnerID=8YFLogxK

U2 - 10.1002/1873-3468.12881

DO - 10.1002/1873-3468.12881

M3 - Article

C2 - 29029363

AN - SCOPUS:85033217630

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

ER -