(Formula Presented) The first syntheses of new antibiotics UPA0043 and UPA0044 were accomplished starting from commercially available 18β-glycyrrhetinic acid and vanillin. The present syntheses involve the coupling of a sesquiterpenoid aldehyde and an aryllithium, the stereoselective formation of a p-quinone-methide system, and regioselective intramolecular cyclization via an epoxy ring opening.
|Number of pages||4|
|Publication status||Published - 2001 Dec 27|
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry