Syntheses of model compounds related to an antigenic epitope in pectic polysaccharides from Bupleurum falcatum L. (II)

Yuhua Jin, Noriyasu Hada, Junko Oka, Osamu Kanie, Shusaku Daikoku, Yoshimi Kanie, Haruki Yamada, Tadahiro Takeda

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Stereocontrolled syntheses of model compounds related to a major antigenic epitope against antibupleurum 2IIc/PG-1-IgG from antiulcer pectic polysaccharide are described. A trisaccharide derivative (13) was prepared as a precursor and a novel and simple approach for the rational design of a glycocluster and glycodendrimer was developed, through the syntheses of the fluorescence-labeled glycocluster (2) and glycodendrimer (3).

Original languageEnglish
Pages (from-to)485-492
Number of pages8
JournalChemical and Pharmaceutical Bulletin
Issue number4
Publication statusPublished - 2006 Apr 1



  • B-alanine derivative
  • Bupleurum falcatum
  • Chemical synthesis
  • Glycocluster
  • Glycodendrimer

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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