Syntheses of model compounds related to an antigenic epitope in pectic polysaccharides from Bupleurum falcatum L. (II)

Yuhua Jin, Noriyasu Hada, Junko Oka, Osamu Kanie, Shusaku Daikoku, Yoshimi Kanie, Haruki Yamada, Tadahiro Takeda

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Stereocontrolled syntheses of model compounds related to a major antigenic epitope against antibupleurum 2IIc/PG-1-IgG from antiulcer pectic polysaccharide are described. A trisaccharide derivative (13) was prepared as a precursor and a novel and simple approach for the rational design of a glycocluster and glycodendrimer was developed, through the syntheses of the fluorescence-labeled glycocluster (2) and glycodendrimer (3).

Original languageEnglish
Pages (from-to)485-492
Number of pages8
JournalChemical and Pharmaceutical Bulletin
Volume54
Issue number4
DOIs
Publication statusPublished - 2006 Apr

Fingerprint

Bupleurum
Polysaccharides
Epitopes
Immunoglobulin G
Fluorescence
Derivatives
A-trisaccharide

Keywords

  • B-alanine derivative
  • Bupleurum falcatum
  • Chemical synthesis
  • Glycocluster
  • Glycodendrimer

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Cite this

Syntheses of model compounds related to an antigenic epitope in pectic polysaccharides from Bupleurum falcatum L. (II). / Jin, Yuhua; Hada, Noriyasu; Oka, Junko; Kanie, Osamu; Daikoku, Shusaku; Kanie, Yoshimi; Yamada, Haruki; Takeda, Tadahiro.

In: Chemical and Pharmaceutical Bulletin, Vol. 54, No. 4, 04.2006, p. 485-492.

Research output: Contribution to journalArticle

Jin, Yuhua ; Hada, Noriyasu ; Oka, Junko ; Kanie, Osamu ; Daikoku, Shusaku ; Kanie, Yoshimi ; Yamada, Haruki ; Takeda, Tadahiro. / Syntheses of model compounds related to an antigenic epitope in pectic polysaccharides from Bupleurum falcatum L. (II). In: Chemical and Pharmaceutical Bulletin. 2006 ; Vol. 54, No. 4. pp. 485-492.
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