Synthesis and antimicrobial properties of amphiphilic sugar derivatives containing sulfur and nitrogen

K. Yago, S. Zen, K. Kawada, T. Uchibori, K. Asakura, S. Matsumura

Research output: Contribution to journalArticle

Abstract

Two series of methyl α-D-glucoside derivatives containing an alkyl chain with 8 to 16 atoms, methyl 6-N-alkylamino-6-deoxy-α-D-glucoside and methyl 6-alkylthio-6-deoxy-α-D-glucoside, were synthesized and their antimicrobial activities were evaluated. All of the compounds tested were found to show inhibitory activities, and these activities were dependent on alkyl chain length. In particular, methyl α-D-glucoside derivatives with a dodecyl group showed considerable inhibitory activity. Among the dodecyl derivatives, the sulfur derivative was more effective than the imino derivative.

Original languageEnglish
Pages (from-to)213-216
Number of pages4
JournalJournal of Antibacterial and Antifungal Agents, Japan
Volume22
Issue number4
Publication statusPublished - 1994 Jan 1
Externally publishedYes

Keywords

  • amphiphilic compound
  • antimicrobial activity
  • methyl glucoside
  • minimal inhibitory
  • sugar derivative

ASJC Scopus subject areas

  • Microbiology

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