Synthesis and antitumor activity of combretastatin D-4

Kanako Uno, Takamasa Tanabe, Takahisa Ogamino, Ryoko Okada, Masaya Imoto, Shigeru Nishiyama

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Combretastatin D-4 1 was synthesized using electrochemical dimerization of phenols as the key step. Anodic oxidation of bromochloro-phenol 7 provided the corresponding diaryl ether 8. Manipulation of the two hydroxyl groups differenciated, provided the seco-acid, which on Mitsunobu reaction gave the target molecule. Its biological assay showed new potent inhibitory activity against cellular proliferation of human HT-29 colon carcinoma cells.

Original languageEnglish
Pages (from-to)291-296
Number of pages6
JournalHeterocycles
Volume75
Issue number2
DOIs
Publication statusPublished - 2008 Feb 1

Keywords

  • Anodic Oxidation
  • Combretastatin D-4
  • Cyclic Diarylheptanoid
  • Getonia floribunda
  • One-Electron Oxidation

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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