Abstract
Combretastatin D-4 1 was synthesized using electrochemical dimerization of phenols as the key step. Anodic oxidation of bromochloro-phenol 7 provided the corresponding diaryl ether 8. Manipulation of the two hydroxyl groups differenciated, provided the seco-acid, which on Mitsunobu reaction gave the target molecule. Its biological assay showed new potent inhibitory activity against cellular proliferation of human HT-29 colon carcinoma cells.
Original language | English |
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Pages (from-to) | 291-296 |
Number of pages | 6 |
Journal | Heterocycles |
Volume | 75 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2008 Feb 1 |
Keywords
- Anodic Oxidation
- Combretastatin D-4
- Cyclic Diarylheptanoid
- Getonia floribunda
- One-Electron Oxidation
ASJC Scopus subject areas
- Analytical Chemistry
- Pharmacology
- Organic Chemistry