Synthesis and biological evaluation of 12,13-cyclopropyl and 12,13-cyclobutyl epothilones

K. C. Nicolaou, Kenji Namoto, Jim Li, Andreas Ritzén, Trond Ulven, Mitsuru Shoji, Dan Zaharevitz, Rick Gussio, Dan L. Sackett, Rita D. Ward, Anne Hensler, Tito Fojo, Paraskevi Giannakakou

Research output: Contribution to journalArticle

35 Citations (Scopus)
Original languageEnglish
Pages (from-to)69-75
Number of pages7
JournalChemBioChem
Volume2
Issue number1
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Epothilones
Thiazoles
Stereoisomerism
Lactones
Tubulin
Biological Products
Antineoplastic Agents
Electron microscopy

Keywords

  • Antitumor agents
  • Epothilones
  • Natural products
  • Structure-activity relationships
  • Synthesis design

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Nicolaou, K. C., Namoto, K., Li, J., Ritzén, A., Ulven, T., Shoji, M., ... Giannakakou, P. (2001). Synthesis and biological evaluation of 12,13-cyclopropyl and 12,13-cyclobutyl epothilones. ChemBioChem, 2(1), 69-75.

Synthesis and biological evaluation of 12,13-cyclopropyl and 12,13-cyclobutyl epothilones. / Nicolaou, K. C.; Namoto, Kenji; Li, Jim; Ritzén, Andreas; Ulven, Trond; Shoji, Mitsuru; Zaharevitz, Dan; Gussio, Rick; Sackett, Dan L.; Ward, Rita D.; Hensler, Anne; Fojo, Tito; Giannakakou, Paraskevi.

In: ChemBioChem, Vol. 2, No. 1, 2001, p. 69-75.

Research output: Contribution to journalArticle

Nicolaou, KC, Namoto, K, Li, J, Ritzén, A, Ulven, T, Shoji, M, Zaharevitz, D, Gussio, R, Sackett, DL, Ward, RD, Hensler, A, Fojo, T & Giannakakou, P 2001, 'Synthesis and biological evaluation of 12,13-cyclopropyl and 12,13-cyclobutyl epothilones', ChemBioChem, vol. 2, no. 1, pp. 69-75.
Nicolaou KC, Namoto K, Li J, Ritzén A, Ulven T, Shoji M et al. Synthesis and biological evaluation of 12,13-cyclopropyl and 12,13-cyclobutyl epothilones. ChemBioChem. 2001;2(1):69-75.
Nicolaou, K. C. ; Namoto, Kenji ; Li, Jim ; Ritzén, Andreas ; Ulven, Trond ; Shoji, Mitsuru ; Zaharevitz, Dan ; Gussio, Rick ; Sackett, Dan L. ; Ward, Rita D. ; Hensler, Anne ; Fojo, Tito ; Giannakakou, Paraskevi. / Synthesis and biological evaluation of 12,13-cyclopropyl and 12,13-cyclobutyl epothilones. In: ChemBioChem. 2001 ; Vol. 2, No. 1. pp. 69-75.
@article{c3915bd004bc4a819ff617d05893c857,
title = "Synthesis and biological evaluation of 12,13-cyclopropyl and 12,13-cyclobutyl epothilones",
keywords = "Antitumor agents, Epothilones, Natural products, Structure-activity relationships, Synthesis design",
author = "Nicolaou, {K. C.} and Kenji Namoto and Jim Li and Andreas Ritz{\'e}n and Trond Ulven and Mitsuru Shoji and Dan Zaharevitz and Rick Gussio and Sackett, {Dan L.} and Ward, {Rita D.} and Anne Hensler and Tito Fojo and Paraskevi Giannakakou",
year = "2001",
language = "English",
volume = "2",
pages = "69--75",
journal = "ChemBioChem",
issn = "1439-4227",
publisher = "Wiley-VCH Verlag",
number = "1",

}

TY - JOUR

T1 - Synthesis and biological evaluation of 12,13-cyclopropyl and 12,13-cyclobutyl epothilones

AU - Nicolaou, K. C.

AU - Namoto, Kenji

AU - Li, Jim

AU - Ritzén, Andreas

AU - Ulven, Trond

AU - Shoji, Mitsuru

AU - Zaharevitz, Dan

AU - Gussio, Rick

AU - Sackett, Dan L.

AU - Ward, Rita D.

AU - Hensler, Anne

AU - Fojo, Tito

AU - Giannakakou, Paraskevi

PY - 2001

Y1 - 2001

KW - Antitumor agents

KW - Epothilones

KW - Natural products

KW - Structure-activity relationships

KW - Synthesis design

UR - http://www.scopus.com/inward/record.url?scp=0035825486&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035825486&partnerID=8YFLogxK

M3 - Article

C2 - 11828429

AN - SCOPUS:0035825486

VL - 2

SP - 69

EP - 75

JO - ChemBioChem

JF - ChemBioChem

SN - 1439-4227

IS - 1

ER -