Synthesis and biological evaluation of a MraY selective analogue of tunicamycins

Kazuki Yamamoto, Toyotaka Sato, Yuta Hikiji, Akira Katsuyama, Takanori Matsumaru, Fumika Yakushiji, Shin Ichi Yokota, Satoshi Ichikawa

Research output: Contribution to journalArticle

Abstract

Tunicamycins, which are nucleoside natural products, inhibit both bacterial phospho-N-acetylmuraminic acid (MurNAc)-pentapeptide translocase (MraY) and human UDP-N-acetylglucosamine (GlcNAc): polyprenol phosphate translocase (GPT). The improved synthesis and detailed biological evaluation of an MraY-selective inhibitor, 2, where the GlcNAc moiety was modified to a MurNAc amide, has been described.

Original languageEnglish
Pages (from-to)349-364
Number of pages16
JournalNucleosides, Nucleotides and Nucleic Acids
Volume39
Issue number1-3
DOIs
Publication statusPublished - 2020 Feb 20

Keywords

  • antibacterial
  • nucleoside natural products
  • organic chemistry

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Genetics

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    Yamamoto, K., Sato, T., Hikiji, Y., Katsuyama, A., Matsumaru, T., Yakushiji, F., Yokota, S. I., & Ichikawa, S. (2020). Synthesis and biological evaluation of a MraY selective analogue of tunicamycins. Nucleosides, Nucleotides and Nucleic Acids, 39(1-3), 349-364. https://doi.org/10.1080/15257770.2019.1649696