Synthesis and biological evaluation on novel analogs of 9-methylstreptimidone, an inhibitor of NF-κB

Yuichi Ishikawa, Miyuki Tachibana, Chino Matsui, Rika Obata, Kazuo Umezawa, Shigeru Nishiyama

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Synthesis of 9-methylstreptimidone analogs and their inhibitory activities against NF-κB (nuclear factor-κB) are reported. Among several active derivatives synthesized in this study, 8 with a relatively simple structure, exhibited inhibitory activity against LPS-induced NO production comparable to that of 9-methylstreptimidone.

Original languageEnglish
Pages (from-to)1726-1728
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number6
DOIs
Publication statusPublished - 2009 Mar 15

Keywords

  • 9-Methylstreptimidone
  • Inhibitor
  • NF-κB

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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