Synthesis and biological evaluation on novel analogs of 9-methylstreptimidone, an inhibitor of NF-κB

Yuichi Ishikawa; Miyuki Tachibana; Chino Matsui; Rika Obata; Kazuo Umezawa; Shigeru Nishiyama

doi:10.1016/j.bmcl.2009.01.107

Synthesis and biological evaluation on novel analogs of 9-methylstreptimidone, an inhibitor of NF-κB

Yuichi Ishikawa, Miyuki Tachibana, Chino Matsui, Rika Obata, Kazuo Umezawa, Shigeru Nishiyama

Department of Humanities and Social Sciences

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Synthesis of 9-methylstreptimidone analogs and their inhibitory activities against NF-κB (nuclear factor-κB) are reported. Among several active derivatives synthesized in this study, 8 with a relatively simple structure, exhibited inhibitory activity against LPS-induced NO production comparable to that of 9-methylstreptimidone.

Original language	English
Pages (from-to)	1726-1728
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	6
DOIs	https://doi.org/10.1016/j.bmcl.2009.01.107
Publication status	Published - 2009 Mar 15

Keywords

9-Methylstreptimidone
Inhibitor
NF-κB

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2009.01.107

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title = "Synthesis and biological evaluation on novel analogs of 9-methylstreptimidone, an inhibitor of NF-κB",

abstract = "Synthesis of 9-methylstreptimidone analogs and their inhibitory activities against NF-κB (nuclear factor-κB) are reported. Among several active derivatives synthesized in this study, 8 with a relatively simple structure, exhibited inhibitory activity against LPS-induced NO production comparable to that of 9-methylstreptimidone.",

keywords = "9-Methylstreptimidone, Inhibitor, NF-κB",

author = "Yuichi Ishikawa and Miyuki Tachibana and Chino Matsui and Rika Obata and Kazuo Umezawa and Shigeru Nishiyama",

note = "Funding Information: This work was supported by High-Tech Research Center Project for Private Universities: matching fund subsidy from MEXT, 2006–2011. ",

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T1 - Synthesis and biological evaluation on novel analogs of 9-methylstreptimidone, an inhibitor of NF-κB

AU - Ishikawa, Yuichi

AU - Tachibana, Miyuki

AU - Matsui, Chino

AU - Obata, Rika

AU - Umezawa, Kazuo

AU - Nishiyama, Shigeru

N1 - Funding Information: This work was supported by High-Tech Research Center Project for Private Universities: matching fund subsidy from MEXT, 2006–2011.

PY - 2009/3/15

Y1 - 2009/3/15

N2 - Synthesis of 9-methylstreptimidone analogs and their inhibitory activities against NF-κB (nuclear factor-κB) are reported. Among several active derivatives synthesized in this study, 8 with a relatively simple structure, exhibited inhibitory activity against LPS-induced NO production comparable to that of 9-methylstreptimidone.

AB - Synthesis of 9-methylstreptimidone analogs and their inhibitory activities against NF-κB (nuclear factor-κB) are reported. Among several active derivatives synthesized in this study, 8 with a relatively simple structure, exhibited inhibitory activity against LPS-induced NO production comparable to that of 9-methylstreptimidone.

KW - 9-Methylstreptimidone

KW - Inhibitor

KW - NF-κB

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 6

ER -

Synthesis and biological evaluation on novel analogs of 9-methylstreptimidone, an inhibitor of NF-κB

Abstract

Keywords

ASJC Scopus subject areas

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