Synthesis and biological properties of partially modified retro and retro-inverso pseudo peptides of Arg-Gly-Asp (RGD)

Naoyuki Nishikawa; Hiroyuki Komazawa; Atsushi Orikasa; Mitsuo Yoshikane; Jiro Yamaguchi; Masayoshi Kojima; Mitsunori Ono; Isamu Itoh; Ichiro Azuma; Hideki Fujii; Jun Murata; Ikuo Saiki

doi:10.1016/S0960-894X(96)00494-5

Synthesis and biological properties of partially modified retro and retro-inverso pseudo peptides of Arg-Gly-Asp (RGD)

Naoyuki Nishikawa, Hiroyuki Komazawa, Atsushi Orikasa, Mitsuo Yoshikane, Jiro Yamaguchi, Masayoshi Kojima, Mitsunori Ono, Isamu Itoh, Ichiro Azuma, Hideki Fujii, Jun Murata, Ikuo Saiki

Research output: Contribution to journal › Article › peer-review

Abstract

Partially modified retro and retro-inverso peptide analogs of Arg-Gly-Asp (RGD) were synthesized and examined their inhibitory effects on experimental lung metastasis of murine melanoma and adenosine 5'-diphosphate (ADP) induced platelet aggregation. The analogs showed efficient therapeutic potency for the tumor metastasis but low inhibitory effect on ADP induced platelet aggregation.

Original language	English
Pages (from-to)	2725-2728
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	6
Issue number	22
DOIs	https://doi.org/10.1016/S0960-894X(96)00494-5
Publication status	Published - 1996 Nov 19
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(96)00494-5

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Nishikawa, N., Komazawa, H., Orikasa, A., Yoshikane, M., Yamaguchi, J., Kojima, M., Ono, M., Itoh, I., Azuma, I., Fujii, H., Murata, J., & Saiki, I. (1996). Synthesis and biological properties of partially modified retro and retro-inverso pseudo peptides of Arg-Gly-Asp (RGD). Bioorganic and Medicinal Chemistry Letters, 6(22), 2725-2728. https://doi.org/10.1016/S0960-894X(96)00494-5

Nishikawa, N, Komazawa, H, Orikasa, A, Yoshikane, M, Yamaguchi, J, Kojima, M, Ono, M, Itoh, I, Azuma, I, Fujii, H, Murata, J & Saiki, I 1996, 'Synthesis and biological properties of partially modified retro and retro-inverso pseudo peptides of Arg-Gly-Asp (RGD)', Bioorganic and Medicinal Chemistry Letters, vol. 6, no. 22, pp. 2725-2728. https://doi.org/10.1016/S0960-894X(96)00494-5

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title = "Synthesis and biological properties of partially modified retro and retro-inverso pseudo peptides of Arg-Gly-Asp (RGD)",

abstract = "Partially modified retro and retro-inverso peptide analogs of Arg-Gly-Asp (RGD) were synthesized and examined their inhibitory effects on experimental lung metastasis of murine melanoma and adenosine 5'-diphosphate (ADP) induced platelet aggregation. The analogs showed efficient therapeutic potency for the tumor metastasis but low inhibitory effect on ADP induced platelet aggregation.",

author = "Naoyuki Nishikawa and Hiroyuki Komazawa and Atsushi Orikasa and Mitsuo Yoshikane and Jiro Yamaguchi and Masayoshi Kojima and Mitsunori Ono and Isamu Itoh and Ichiro Azuma and Hideki Fujii and Jun Murata and Ikuo Saiki",

note = "Funding Information: Acknowledgment: This work was supported in part by Grants-in-Aid for Cancer Research from the Japanese Ministry of Education, Science and Culture (No. 06282122 & 07273106).",

year = "1996",

month = nov,

day = "19",

doi = "10.1016/S0960-894X(96)00494-5",

language = "English",

volume = "6",

pages = "2725--2728",

journal = "Bioorganic and Medicinal Chemistry Letters",

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TY - JOUR

T1 - Synthesis and biological properties of partially modified retro and retro-inverso pseudo peptides of Arg-Gly-Asp (RGD)

AU - Nishikawa, Naoyuki

AU - Komazawa, Hiroyuki

AU - Orikasa, Atsushi

AU - Yoshikane, Mitsuo

AU - Yamaguchi, Jiro

AU - Kojima, Masayoshi

AU - Ono, Mitsunori

AU - Itoh, Isamu

AU - Azuma, Ichiro

AU - Fujii, Hideki

AU - Murata, Jun

AU - Saiki, Ikuo

N1 - Funding Information: Acknowledgment: This work was supported in part by Grants-in-Aid for Cancer Research from the Japanese Ministry of Education, Science and Culture (No. 06282122 & 07273106).

PY - 1996/11/19

Y1 - 1996/11/19

N2 - Partially modified retro and retro-inverso peptide analogs of Arg-Gly-Asp (RGD) were synthesized and examined their inhibitory effects on experimental lung metastasis of murine melanoma and adenosine 5'-diphosphate (ADP) induced platelet aggregation. The analogs showed efficient therapeutic potency for the tumor metastasis but low inhibitory effect on ADP induced platelet aggregation.

AB - Partially modified retro and retro-inverso peptide analogs of Arg-Gly-Asp (RGD) were synthesized and examined their inhibitory effects on experimental lung metastasis of murine melanoma and adenosine 5'-diphosphate (ADP) induced platelet aggregation. The analogs showed efficient therapeutic potency for the tumor metastasis but low inhibitory effect on ADP induced platelet aggregation.

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

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ER -

Synthesis and biological properties of partially modified retro and retro-inverso pseudo peptides of Arg-Gly-Asp (RGD)

Abstract

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