Synthesis and evaluation of isomers of melleumin B from the myxomycete Physarum melleum; an approach for Wnt signal inhibitor trusted in nature

Midori A. Arai, Yujiro Uchino, Shuwa Hanazawa, Xiaofan Li, Naoki Kimura, Masami Ishibashi

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Two stereoisomers of melleumin B (1), seco acid methyl ester of melleumin A (2), which are novel peptide compounds isolated from the myxomycete Physarum melleum, were synthesized and evaluated for their inhibition of Wnt signal transcription. The 3R-epimer and (3R, 4S, 10R, 11R)-isomer of 1 showed moderate inhibition of the Wnt signal.

Original languageEnglish
Pages (from-to)1425-1438
Number of pages14
JournalHeterocycles
Volume76
Issue number2
DOIs
Publication statusPublished - 2008 Nov 1
Externally publishedYes

Keywords

  • Inhibitor
  • Myxomycete
  • Peptide
  • Stereoisomer
  • Wnt Signal

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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