Synthesis and functional analysis of the key compounds responsible for signal transduction

Research output: Contribution to journalArticle

Abstract

Signal transduction systems for detection of surrounding information are the one of essential functions for life. One of these systems is the sensory system such as vision, olfactory and gustatory. The innate immune system is also fundamental to protect our body, which basically senses microbial components by receptor proteins. In order to elucidate the function of the key molecules in the signal transduction, we have studied it on the view of organic chemistry. Here, the results on the following key compounds will be shown; one is 11-cis-retinal in a light-receptor rhodopsin essential in vision, and the others are bacterial lipopolysaccharide and peptideglycan in the innate immune system.

Original languageEnglish
Pages (from-to)1170-1178
Number of pages9
JournalYuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
Volume65
Issue number12
DOIs
Publication statusPublished - 2007 Dec
Externally publishedYes

Keywords

  • 11-cis-retinal
  • Innate immune system
  • Lipopolysaccharide
  • Peptidoglycan
  • Rhodopsin
  • Signal transduction
  • Vision

ASJC Scopus subject areas

  • Organic Chemistry

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