Synthesis and nematocidal activity of diarylnonanoids related to malabaricones

Shinzo Hosoi, Fumiyuki Kiuchi, Norio Nakamura, Masaaki Imasho, Mohammad Ahad Ali, Youhei Sasaki, Eriko Tanaka, Yoshiyuki Tsumamoto, Kaoru Kondo, Yoshisuke Tsuda

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Twenty diarylnonanones were synthesized and their nematocidal activity was examined. Among those, the p-hydroxy compound 16 exhibited the strongest activity comparable to the natural diarylnonanoids, malabaricones A and C. Diarylundecanoid 57 also showed appreciable activity.

Original languageEnglish
Pages (from-to)37-43
Number of pages7
JournalChemical and Pharmaceutical Bulletin
Volume47
Issue number1
Publication statusPublished - 1999 Jan
Externally publishedYes

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malabaricone A
malabaricone C

Keywords

  • Diarylnonanoid
  • Diarylundecanoid
  • Malabaricone
  • Nematocidal activity
  • Structure-activity relationship
  • Toxocara canis

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Cite this

Hosoi, S., Kiuchi, F., Nakamura, N., Imasho, M., Ali, M. A., Sasaki, Y., ... Tsuda, Y. (1999). Synthesis and nematocidal activity of diarylnonanoids related to malabaricones. Chemical and Pharmaceutical Bulletin, 47(1), 37-43.

Synthesis and nematocidal activity of diarylnonanoids related to malabaricones. / Hosoi, Shinzo; Kiuchi, Fumiyuki; Nakamura, Norio; Imasho, Masaaki; Ali, Mohammad Ahad; Sasaki, Youhei; Tanaka, Eriko; Tsumamoto, Yoshiyuki; Kondo, Kaoru; Tsuda, Yoshisuke.

In: Chemical and Pharmaceutical Bulletin, Vol. 47, No. 1, 01.1999, p. 37-43.

Research output: Contribution to journalArticle

Hosoi, S, Kiuchi, F, Nakamura, N, Imasho, M, Ali, MA, Sasaki, Y, Tanaka, E, Tsumamoto, Y, Kondo, K & Tsuda, Y 1999, 'Synthesis and nematocidal activity of diarylnonanoids related to malabaricones', Chemical and Pharmaceutical Bulletin, vol. 47, no. 1, pp. 37-43.
Hosoi, Shinzo ; Kiuchi, Fumiyuki ; Nakamura, Norio ; Imasho, Masaaki ; Ali, Mohammad Ahad ; Sasaki, Youhei ; Tanaka, Eriko ; Tsumamoto, Yoshiyuki ; Kondo, Kaoru ; Tsuda, Yoshisuke. / Synthesis and nematocidal activity of diarylnonanoids related to malabaricones. In: Chemical and Pharmaceutical Bulletin. 1999 ; Vol. 47, No. 1. pp. 37-43.
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