Synthesis and properties of novel gels based on cyclic acetal

Sachiko Kaihara, Parth Modi, Jennifer Curcio, Kazunobu Toshima, John Fisher, Shuichi Matsumura

Research output: Contribution to conferencePaper

Abstract

A series of novel hydrogels containing cyclic acetal and PEG in backbone were synthesized to prevent inflammatory responses caused by acidic degradation products of biodegradable polymer such as PLA. Cyclic acetal will be degraded to produce alcohol and carbonyl terminals as degradation products so that it will not cause inflammatory responses. The structures of the synthesized hydrogels were analyzed by using 1H-NMR, GPC, FT-IR and MALDI-TOF MS. Properties of synthesized hydrogels, such as cell adhesion, viability and swelling degree, were explored. It was confirmed that synthesized hydrogels showed a high cell viability, therefore they had a sufficient biocompatibility. The swelling degrees of hydrgels were controllable by means of the reaction conditions.

Original languageEnglish
Pages5406-5407
Number of pages2
Publication statusPublished - 2006 Dec 1
Event55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan
Duration: 2006 Sep 202006 Sep 22

Other

Other55th Society of Polymer Science Japan Symposium on Macromolecules
CountryJapan
CityToyama
Period06/9/2006/9/22

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Keywords

  • Biomaterial
  • Cyclic aetal
  • Gel

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Kaihara, S., Modi, P., Curcio, J., Toshima, K., Fisher, J., & Matsumura, S. (2006). Synthesis and properties of novel gels based on cyclic acetal. 5406-5407. Paper presented at 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, Japan.