Synthesis and properties of novel gels based on cyclic acetal

Sachiko Kaihara, Parth Modi, Jennifer Curcio, Kazunobu Toshima, John Fisher, Shuichi Matsumura

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A series of novel hydrogels containing cyclic acetal and PEG in backbone were synthesized to prevent inflammatory responses caused by acidic degradation products of biodegradable polymer such as PLA. Cyclic acetal will be degraded to produce alcohol and carbonyl terminals as degradation products so that it will not cause inflammatory responses. The structures of the synthesized hydrogels were analyzed by using 1H-NMR, GPC, FT-IR and MALDI-TOF MS. Properties of synthesized hydrogels, such as cell adhesion, viability and swelling degree, were explored. It was confirmed that synthesized hydrogels showed a high cell viability, therefore they had a sufficient biocompatibility. The swelling degrees of hydrgels were controllable by means of the reaction conditions.

Original languageEnglish
Title of host publicationPolymer Preprints, Japan
Pages5406-5407
Number of pages2
Volume55
Edition2
Publication statusPublished - 2006
Event55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan
Duration: 2006 Sep 202006 Sep 22

Other

Other55th Society of Polymer Science Japan Symposium on Macromolecules
CountryJapan
CityToyama
Period06/9/2006/9/22

Fingerprint

Hydrogels
Gels
Swelling
Degradation
Biodegradable polymers
Cell adhesion
Biocompatibility
Polyethylene glycols
Alcohols
Cells
Nuclear magnetic resonance

Keywords

  • Biomaterial
  • Cyclic aetal
  • Gel

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Kaihara, S., Modi, P., Curcio, J., Toshima, K., Fisher, J., & Matsumura, S. (2006). Synthesis and properties of novel gels based on cyclic acetal. In Polymer Preprints, Japan (2 ed., Vol. 55, pp. 5406-5407)

Synthesis and properties of novel gels based on cyclic acetal. / Kaihara, Sachiko; Modi, Parth; Curcio, Jennifer; Toshima, Kazunobu; Fisher, John; Matsumura, Shuichi.

Polymer Preprints, Japan. Vol. 55 2. ed. 2006. p. 5406-5407.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kaihara, S, Modi, P, Curcio, J, Toshima, K, Fisher, J & Matsumura, S 2006, Synthesis and properties of novel gels based on cyclic acetal. in Polymer Preprints, Japan. 2 edn, vol. 55, pp. 5406-5407, 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, Japan, 06/9/20.
Kaihara S, Modi P, Curcio J, Toshima K, Fisher J, Matsumura S. Synthesis and properties of novel gels based on cyclic acetal. In Polymer Preprints, Japan. 2 ed. Vol. 55. 2006. p. 5406-5407
Kaihara, Sachiko ; Modi, Parth ; Curcio, Jennifer ; Toshima, Kazunobu ; Fisher, John ; Matsumura, Shuichi. / Synthesis and properties of novel gels based on cyclic acetal. Polymer Preprints, Japan. Vol. 55 2. ed. 2006. pp. 5406-5407
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