Synthesis and structure - Activity relationships of 1-phenylpyrazoles as xanthine oxidase inhibitors

Seigo Ishibuchi, Hiroshi Morimoto, Takanori Oe, Tsuguo Ikebe, Hiroyoshi Inoue, Atsushi Fukunari, Miho Kamezawa, Ichimaro Yamada, Yoichi Naka

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

A series of 1-phenylpyrazoles was evaluated for inhibitory activity against xanthine oxidase in vitro. Of the compounds prepared, 1-(3-cyano-4-neopentyloxyphenyl)pyrazole-4-carboxylic acid (Y-700) had the most potent enzyme inhibition and displayed longer-lasting hypouricemic action than did allopurinol in a rat model of hyperuricemia induced by the uricase inhibitor potassium oxonate.

Original languageEnglish
Pages (from-to)879-882
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume11
Issue number7
DOIs
Publication statusPublished - 2001 Apr 9
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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