Synthesis of (2S,5S)-bishydroxymethyl-(3R,4R)-bishydroxypyrrolidine from D-mannitol

Tony K.M. Shing

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

A short, efficient, and practical synthesis of (2S,5S)-bishydroxymethyl-(3R,4R)-bishydroxypyrrolidine from D-mannitol involving five sequential reactions (benzylidenation, trifluoromethanesulphonation, hydrazinolysis, hydrogenolysis, and deacetalisation) is described.

Original languageEnglish
Pages (from-to)7261-7264
Number of pages4
JournalTetrahedron
Volume44
Issue number23
DOIs
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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