Synthesis of 3-deoxy-D-manno-octulosonic acid (KDO)

Peter M. Collins, W. George Overend, Tony Shing

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Abstract

2,3:5,6-Di-O-isopropylidene-D-mannose has been converted by five sequential reactions (Wittig reaction, deacetonation, hydrogenation, lactonisation, and isopropylidenation) into 2,3-dideoxy-5,6:7,8-di-O-isopropylidene-D-octonolactone which in a Wasserman reaction gave an α-ketolactone from which KDO could readily be obtained by hydrolysis.

Original languageEnglish
Pages (from-to)1139-1140
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number21
DOIs
Publication statusPublished - 1981 Jan 1

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ASJC Scopus subject areas

  • Molecular Medicine

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