Synthesis of a novel class of cdc25A inhibitors from Vitamin D3

Kosuke Dodo; Masato Takahashi; Yuji Yamada; Yoshikazu Sugimoto; Yuichi Hashimoto; Ryuichi Shirai

doi:10.1016/S0960-894X(00)00065-2

Synthesis of a novel class of cdc25A inhibitors from Vitamin D₃

Kosuke Dodo, Masato Takahashi, Yuji Yamada, Yoshikazu Sugimoto, Yuichi Hashimoto, Ryuichi Shirai

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

We have developed a novel class of cdc25A inhibitors by drastic modification of hydrophobic and hydrophillic substructures of dysidiolide. The unsaturated derivative 3b strongly inhibited cdc25A (IC₅₀=7.7 μM) and caused G1 arrest of HL60 cells. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original language	English
Pages (from-to)	615-617
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	10
Issue number	7
DOIs	https://doi.org/10.1016/S0960-894X(00)00065-2
Publication status	Published - 2000 Apr 3
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(00)00065-2

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title = "Synthesis of a novel class of cdc25A inhibitors from Vitamin D3",

abstract = "We have developed a novel class of cdc25A inhibitors by drastic modification of hydrophobic and hydrophillic substructures of dysidiolide. The unsaturated derivative 3b strongly inhibited cdc25A (IC50=7.7 μM) and caused G1 arrest of HL60 cells. (C) 2000 Elsevier Science Ltd. All rights reserved.",

author = "Kosuke Dodo and Masato Takahashi and Yuji Yamada and Yoshikazu Sugimoto and Yuichi Hashimoto and Ryuichi Shirai",

note = "Funding Information: We are grateful to Professor T. Tsuruo and Dr. A. Tomida (Institute of Molecular and Cellular Biosciences, The University of Tokyo) for helpful discussions about the flow cytometric analysis. This work was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture, Japan.",

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T1 - Synthesis of a novel class of cdc25A inhibitors from Vitamin D3

AU - Dodo, Kosuke

AU - Takahashi, Masato

AU - Yamada, Yuji

AU - Sugimoto, Yoshikazu

AU - Hashimoto, Yuichi

AU - Shirai, Ryuichi

N1 - Funding Information: We are grateful to Professor T. Tsuruo and Dr. A. Tomida (Institute of Molecular and Cellular Biosciences, The University of Tokyo) for helpful discussions about the flow cytometric analysis. This work was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture, Japan.

PY - 2000/4/3

Y1 - 2000/4/3

N2 - We have developed a novel class of cdc25A inhibitors by drastic modification of hydrophobic and hydrophillic substructures of dysidiolide. The unsaturated derivative 3b strongly inhibited cdc25A (IC50=7.7 μM) and caused G1 arrest of HL60 cells. (C) 2000 Elsevier Science Ltd. All rights reserved.

AB - We have developed a novel class of cdc25A inhibitors by drastic modification of hydrophobic and hydrophillic substructures of dysidiolide. The unsaturated derivative 3b strongly inhibited cdc25A (IC50=7.7 μM) and caused G1 arrest of HL60 cells. (C) 2000 Elsevier Science Ltd. All rights reserved.

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Synthesis of a novel class of cdc25A inhibitors from Vitamin D₃

Abstract

ASJC Scopus subject areas

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