Synthesis of a novel class of cdc25A inhibitors from Vitamin D3

Kosuke Dodo, Masato Takahashi, Yuji Yamada, Yoshikazu Sugimoto, Yuichi Hashimoto, Ryuichi Shirai

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We have developed a novel class of cdc25A inhibitors by drastic modification of hydrophobic and hydrophillic substructures of dysidiolide. The unsaturated derivative 3b strongly inhibited cdc25A (IC50=7.7 μM) and caused G1 arrest of HL60 cells. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)615-617
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume10
Issue number7
DOIs
Publication statusPublished - 2000 Apr 3
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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