Synthesis of actin-depolymerizing compounds

Kazuhiro Kitamura, Toshiaki Teruya, Takeshi Kuroda, Hideo Kigoshi, Kiyotake Suenaga

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The artificial actin-depolymerizing compounds 3-6, based on aplyronine A, an actin-depolymerizing antitumor marine macrolide, were synthesized, and their actin-depolymerizing activities and cytotoxicities were evaluated.

Original languageEnglish
Pages (from-to)1896-1898
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number7
DOIs
Publication statusPublished - 2009 Apr 1

Fingerprint

Actins
Macrolides
Cytotoxicity
aplyronine A

Keywords

  • Actin
  • Actin-depolymerizing activity
  • Aplyronine A
  • Cytotoxicity
  • Synthesis

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Cite this

Synthesis of actin-depolymerizing compounds. / Kitamura, Kazuhiro; Teruya, Toshiaki; Kuroda, Takeshi; Kigoshi, Hideo; Suenaga, Kiyotake.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 19, No. 7, 01.04.2009, p. 1896-1898.

Research output: Contribution to journalArticle

Kitamura, Kazuhiro ; Teruya, Toshiaki ; Kuroda, Takeshi ; Kigoshi, Hideo ; Suenaga, Kiyotake. / Synthesis of actin-depolymerizing compounds. In: Bioorganic and Medicinal Chemistry Letters. 2009 ; Vol. 19, No. 7. pp. 1896-1898.
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