Synthesis of actin-depolymerizing compounds

Kazuhiro Kitamura; Toshiaki Teruya; Takeshi Kuroda; Hideo Kigoshi; Kiyotake Suenaga

doi:10.1016/j.bmcl.2009.02.068

Synthesis of actin-depolymerizing compounds

Kazuhiro Kitamura, Toshiaki Teruya, Takeshi Kuroda, Hideo Kigoshi, Kiyotake Suenaga

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The artificial actin-depolymerizing compounds 3-6, based on aplyronine A, an actin-depolymerizing antitumor marine macrolide, were synthesized, and their actin-depolymerizing activities and cytotoxicities were evaluated.

Original language	English
Pages (from-to)	1896-1898
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	7
DOIs	https://doi.org/10.1016/j.bmcl.2009.02.068
Publication status	Published - 2009 Apr 1

Keywords

Actin
Actin-depolymerizing activity
Aplyronine A
Cytotoxicity
Synthesis

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2009.02.068

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@article{8990585e6abd4eddb344958d4b2dde4f,

title = "Synthesis of actin-depolymerizing compounds",

abstract = "The artificial actin-depolymerizing compounds 3-6, based on aplyronine A, an actin-depolymerizing antitumor marine macrolide, were synthesized, and their actin-depolymerizing activities and cytotoxicities were evaluated.",

keywords = "Actin, Actin-depolymerizing activity, Aplyronine A, Cytotoxicity, Synthesis",

author = "Kazuhiro Kitamura and Toshiaki Teruya and Takeshi Kuroda and Hideo Kigoshi and Kiyotake Suenaga",

note = "Funding Information: This work was supported in part by a Grant-in-Aid for Young Scientists (No. 18710180) from the Ministry of Education, Culture, Sports, Science and Technology, Japan, Keio Gijuku Academic Development Funds, and the Asahi Glass Foundation.",

year = "2009",

month = apr,

day = "1",

doi = "10.1016/j.bmcl.2009.02.068",

language = "English",

volume = "19",

pages = "1896--1898",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "7",

}

TY - JOUR

T1 - Synthesis of actin-depolymerizing compounds

AU - Kitamura, Kazuhiro

AU - Teruya, Toshiaki

AU - Kuroda, Takeshi

AU - Kigoshi, Hideo

AU - Suenaga, Kiyotake

N1 - Funding Information: This work was supported in part by a Grant-in-Aid for Young Scientists (No. 18710180) from the Ministry of Education, Culture, Sports, Science and Technology, Japan, Keio Gijuku Academic Development Funds, and the Asahi Glass Foundation.

PY - 2009/4/1

Y1 - 2009/4/1

N2 - The artificial actin-depolymerizing compounds 3-6, based on aplyronine A, an actin-depolymerizing antitumor marine macrolide, were synthesized, and their actin-depolymerizing activities and cytotoxicities were evaluated.

AB - The artificial actin-depolymerizing compounds 3-6, based on aplyronine A, an actin-depolymerizing antitumor marine macrolide, were synthesized, and their actin-depolymerizing activities and cytotoxicities were evaluated.

KW - Actin

KW - Actin-depolymerizing activity

KW - Aplyronine A

KW - Cytotoxicity

KW - Synthesis

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U2 - 10.1016/j.bmcl.2009.02.068

DO - 10.1016/j.bmcl.2009.02.068

M3 - Article

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AN - SCOPUS:61849111296

SN - 0960-894X

VL - 19

SP - 1896

EP - 1898

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 7

ER -

Synthesis of actin-depolymerizing compounds

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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