Synthesis of actin-depolymerizing compounds

Kazuhiro Kitamura, Toshiaki Teruya, Takeshi Kuroda, Hideo Kigoshi, Kiyotake Suenaga

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The artificial actin-depolymerizing compounds 3-6, based on aplyronine A, an actin-depolymerizing antitumor marine macrolide, were synthesized, and their actin-depolymerizing activities and cytotoxicities were evaluated.

Original languageEnglish
Pages (from-to)1896-1898
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number7
DOIs
Publication statusPublished - 2009 Apr 1

Keywords

  • Actin
  • Actin-depolymerizing activity
  • Aplyronine A
  • Cytotoxicity
  • Synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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