Synthesis of carbocyclic analogues of 3-deoxy-d-manno-2-octulosonic acid and N-acetylneuraminic acid

Seiichiro Ogawa, Masaru Yoshikawa, Toshihide Taki, Shigeki Yokoi, Noritaka Chida

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A carbocyclic analogue of N-acetylneuraminic acid was synthesised from the Diels-Alder endo-adduct of furan and acrylic acid, and its ammonium salt was subjected to bioassay. In addition, carbocyclic analogues of 3-deoxy-d-manno-2-octulosonic acid were synthesised in racemic form from the same synthetic intermediate.

Original languageEnglish
Pages (from-to)53-78
Number of pages26
JournalCarbohydrate Research
Volume269
Issue number1
DOIs
Publication statusPublished - 1995 Apr 3

Keywords

  • Carba-sugars
  • Carbocyclic Kdo-analogues
  • Carbocyclic Neu5Ac-analogues
  • Cyclitols
  • Sialidase inhibitors

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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