Synthesis of crosslinked peptidoglycan fragments for investigation of their immunobiological functions

Yukari Fujimoto, Yasuko Konishi, Osamu Kubo, Mizuho Hasegawa, Naohiro Inohara, Koichi Fukase

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The synthesis of crosslinked peptidoglycan (PGN) fragments from Streptococcus pneumoniae cell wall was achieved. The immunostimulatory activities, including the induction of IL-6 and the stimulation of the intracellular receptor Nod2, were also determined. The crosslinked PGN fragments were not major human Nod2 ligands.

Original languageEnglish
Pages (from-to)3631-3634
Number of pages4
JournalTetrahedron Letters
Volume50
Issue number26
DOIs
Publication statusPublished - 2009 Jul 1
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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