Synthesis of crosslinked peptidoglycan fragments for investigation of their immunobiological functions

Yukari Fujimoto, Yasuko Konishi, Osamu Kubo, Mizuho Hasegawa, Naohiro Inohara, Koichi Fukase

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The synthesis of crosslinked peptidoglycan (PGN) fragments from Streptococcus pneumoniae cell wall was achieved. The immunostimulatory activities, including the induction of IL-6 and the stimulation of the intracellular receptor Nod2, were also determined. The crosslinked PGN fragments were not major human Nod2 ligands.

Original languageEnglish
Pages (from-to)3631-3634
Number of pages4
JournalTetrahedron Letters
Volume50
Issue number26
DOIs
Publication statusPublished - 2009 Jul 1
Externally publishedYes

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Peptidoglycan
Streptococcus pneumoniae
Cell Wall
Interleukin-6
Cells
Ligands

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Synthesis of crosslinked peptidoglycan fragments for investigation of their immunobiological functions. / Fujimoto, Yukari; Konishi, Yasuko; Kubo, Osamu; Hasegawa, Mizuho; Inohara, Naohiro; Fukase, Koichi.

In: Tetrahedron Letters, Vol. 50, No. 26, 01.07.2009, p. 3631-3634.

Research output: Contribution to journalArticle

Fujimoto, Yukari ; Konishi, Yasuko ; Kubo, Osamu ; Hasegawa, Mizuho ; Inohara, Naohiro ; Fukase, Koichi. / Synthesis of crosslinked peptidoglycan fragments for investigation of their immunobiological functions. In: Tetrahedron Letters. 2009 ; Vol. 50, No. 26. pp. 3631-3634.
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