Abstract
Fisetin and 2′,4′,6′-trihydroxydihyrochalcone 4′-O-β-neohesperidoside were synthesized from commercially available quercetin and naringin in five steps. The key steps are site-selective deacetylation and subsequent deoxygenation. The target molecules were obtained in 37% and 23% yields from the starting materials, respectively.
| Original language | English |
|---|---|
| Pages (from-to) | 1316-1322 |
| Number of pages | 7 |
| Journal | Bioscience, Biotechnology and Biochemistry |
| Volume | 82 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2018 Jan 1 |
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Keywords
- Deoxygenation
- Dihydrochalcone glycoside
- Fisetin
- Site-selective deacetylation
- Triflate
ASJC Scopus subject areas
- Biotechnology
- Analytical Chemistry
- Biochemistry
- Applied Microbiology and Biotechnology
- Molecular Biology
- Organic Chemistry
Cite this
Synthesis of fisetin and 2′,4′,6′-trihydroxydihyrochalcone 4′-O-β-neohesperidoside based on site-selective deacetylation and deoxygenation. / Tsunekawa, Ryuji; Hanaya, Kengo; Higashibayashi, Shuhei; Sugai, Takeshi.
In: Bioscience, Biotechnology and Biochemistry, Vol. 82, No. 8, 01.01.2018, p. 1316-1322.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis of fisetin and 2′,4′,6′-trihydroxydihyrochalcone 4′-O-β-neohesperidoside based on site-selective deacetylation and deoxygenation
AU - Tsunekawa, Ryuji
AU - Hanaya, Kengo
AU - Higashibayashi, Shuhei
AU - Sugai, Takeshi
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Fisetin and 2′,4′,6′-trihydroxydihyrochalcone 4′-O-β-neohesperidoside were synthesized from commercially available quercetin and naringin in five steps. The key steps are site-selective deacetylation and subsequent deoxygenation. The target molecules were obtained in 37% and 23% yields from the starting materials, respectively.
AB - Fisetin and 2′,4′,6′-trihydroxydihyrochalcone 4′-O-β-neohesperidoside were synthesized from commercially available quercetin and naringin in five steps. The key steps are site-selective deacetylation and subsequent deoxygenation. The target molecules were obtained in 37% and 23% yields from the starting materials, respectively.
KW - Deoxygenation
KW - Dihydrochalcone glycoside
KW - Fisetin
KW - Site-selective deacetylation
KW - Triflate
UR - http://www.scopus.com/inward/record.url?scp=85051641053&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85051641053&partnerID=8YFLogxK
U2 - 10.1080/09168451.2018.1467263
DO - 10.1080/09168451.2018.1467263
M3 - Article
C2 - 29699439
AN - SCOPUS:85051641053
VL - 82
SP - 1316
EP - 1322
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
SN - 0916-8451
IS - 8
ER -