Abstract
Fisetin and 2′,4′,6′-trihydroxydihyrochalcone 4′-O-β-neohesperidoside were synthesized from commercially available quercetin and naringin in five steps. The key steps are site-selective deacetylation and subsequent deoxygenation. The target molecules were obtained in 37% and 23% yields from the starting materials, respectively.
| Original language | English |
|---|---|
| Pages (from-to) | 1316-1322 |
| Number of pages | 7 |
| Journal | Bioscience, Biotechnology and Biochemistry |
| Volume | 82 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2018 Jan 1 |
Keywords
- Deoxygenation
- Dihydrochalcone glycoside
- Fisetin
- Site-selective deacetylation
- Triflate
ASJC Scopus subject areas
- Biotechnology
- Analytical Chemistry
- Biochemistry
- Applied Microbiology and Biotechnology
- Molecular Biology
- Organic Chemistry
Fingerprint Dive into the research topics of 'Synthesis of fisetin and 2′,4′,6′-trihydroxydihyrochalcone 4′-O-β-neohesperidoside based on site-selective deacetylation and deoxygenation'. Together they form a unique fingerprint.
Cite this
Tsunekawa, R., Hanaya, K., Higashibayashi, S., & Sugai, T. (2018). Synthesis of fisetin and 2′,4′,6′-trihydroxydihyrochalcone 4′-O-β-neohesperidoside based on site-selective deacetylation and deoxygenation. Bioscience, Biotechnology and Biochemistry, 82(8), 1316-1322. https://doi.org/10.1080/09168451.2018.1467263