TY - JOUR
T1 - Synthesis of fisetin and 2′,4′,6′-trihydroxydihyrochalcone 4′-O-β-neohesperidoside based on site-selective deacetylation and deoxygenation
AU - Tsunekawa, Ryuji
AU - Hanaya, Kengo
AU - Higashibayashi, Shuhei
AU - Sugai, Takeshi
N1 - Funding Information:
This work was supported by JSPS KAKENHI (16K21362) for K. H. and by a grant from a public interest incorporated foundation “Amano Institute of Technology” for T. S. and are gratefully acknowledged with thanks.
Publisher Copyright:
© 2018 Japan society for Bioscience, Biotechnology, and Agrochemistry.
PY - 2018
Y1 - 2018
N2 - Fisetin and 2′,4′,6′-trihydroxydihyrochalcone 4′-O-β-neohesperidoside were synthesized from commercially available quercetin and naringin in five steps. The key steps are site-selective deacetylation and subsequent deoxygenation. The target molecules were obtained in 37% and 23% yields from the starting materials, respectively.
AB - Fisetin and 2′,4′,6′-trihydroxydihyrochalcone 4′-O-β-neohesperidoside were synthesized from commercially available quercetin and naringin in five steps. The key steps are site-selective deacetylation and subsequent deoxygenation. The target molecules were obtained in 37% and 23% yields from the starting materials, respectively.
KW - Deoxygenation
KW - Dihydrochalcone glycoside
KW - Fisetin
KW - Site-selective deacetylation
KW - Triflate
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U2 - 10.1080/09168451.2018.1467263
DO - 10.1080/09168451.2018.1467263
M3 - Article
C2 - 29699439
AN - SCOPUS:85051641053
VL - 82
SP - 1316
EP - 1322
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
SN - 0916-8451
IS - 8
ER -