Synthesis of fluorescent substrates for protein tyrosine phosphatase assays

Takumi Watanabe, Masaya Imoto, Hiroki Taniguchi, Kazuhiko Kinoshita, Kazuo Umezawa

Research output: Contribution to journalArticlepeer-review

Abstract

Two fluorescent substrates for protein tyrosine phosphatase (PTPase) reaction were prepared by conjugation of commercially available O- phosphotyrosine and dansyl chlorides. They were hydrolyzed by CD45 tyrosine phosphatase, and proved to be useful for PTPase assay.

Original languageEnglish
Pages (from-to)1301-1302
Number of pages2
JournalBioorganic and Medicinal Chemistry Letters
Volume8
Issue number11
DOIs
Publication statusPublished - 1998 Jun 2

Keywords

  • Amino acids and derivatives
  • Enzyme inhibitors
  • Fluorescence

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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