Abstract
As a part of a exploring the N-glycan-mediated glycoprotein quality control in endoplasmic reticulum, 2-fluorinated derivative Glcα1 → 3Man(F) 1, Glcα1 → 3Man(F)α1 → 2Man2, and Glcα1 → 3Man(F)α1 → 2Manα1 → 2Man 3 were synthesized in a concise manner. These oligosaccharides were subjected to binding studies with calreticulin by using isothermal titration calorimetry. It was revealed that disaccharide 1 was a poor ligand, while tri- (2) and tetrasaccharide (3) had observable affinity.
| Original language | English |
|---|---|
| Pages (from-to) | 257-266 |
| Number of pages | 10 |
| Journal | Glycoconjugate Journal |
| Volume | 21 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2004 Nov 1 |
| Externally published | Yes |
Keywords
- 2-fluorinated oligosaccharide
- calreticulin
- glycoprotein quality control
- synthesis
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology
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Ito, Y., Hagihara, S., Arai, M. A., Matsuo, I., & Takatani, M. (2004). Synthesis of fluorine substituted oligosaccharide analogues of monoglucosylated glycan chain, a proposed ligand of lectin-chaperone calreticulin and calnexin. Glycoconjugate Journal, 21(5), 257-266. https://doi.org/10.1023/B:GLYC.0000045109.60425.2e