Synthesis of fused tetracyclic spiroindoles via palladium-catalysed cascade cyclisation

Akira Iwata, Shinsuke Inuki, Shinya Oishi, Nobutaka Fujii, Hiroaki Ohno

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Efficient palladium-catalysed cascade cyclisation to form spiroindoles is developed. Treatment of indoles bearing a propargyl chloride side chain at the 3-position with various external nucleophiles in the presence of a catalytic amount of Pd2(dba)3·CHCl3/dppb and Cs2CO3 in THF gives fused tetracyclic spiroindoles in moderate to good yields.

Original languageEnglish
Pages (from-to)298-300
Number of pages3
JournalChemical Communications
Volume50
Issue number3
DOIs
Publication statusPublished - 2014 Jan 11
Externally publishedYes

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Bearings (structural)
Indoles
Nucleophiles
Cyclization
Palladium
Chlorides

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

Cite this

Synthesis of fused tetracyclic spiroindoles via palladium-catalysed cascade cyclisation. / Iwata, Akira; Inuki, Shinsuke; Oishi, Shinya; Fujii, Nobutaka; Ohno, Hiroaki.

In: Chemical Communications, Vol. 50, No. 3, 11.01.2014, p. 298-300.

Research output: Contribution to journalArticle

Iwata, Akira ; Inuki, Shinsuke ; Oishi, Shinya ; Fujii, Nobutaka ; Ohno, Hiroaki. / Synthesis of fused tetracyclic spiroindoles via palladium-catalysed cascade cyclisation. In: Chemical Communications. 2014 ; Vol. 50, No. 3. pp. 298-300.
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