Synthesis of fused tetracyclic spiroindoles via palladium-catalysed cascade cyclisation

Akira Iwata; Shinsuke Inuki; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

doi:10.1039/c3cc46511j

Synthesis of fused tetracyclic spiroindoles via palladium-catalysed cascade cyclisation

Akira Iwata, Shinsuke Inuki, Shinya Oishi, Nobutaka Fujii, Hiroaki Ohno

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Efficient palladium-catalysed cascade cyclisation to form spiroindoles is developed. Treatment of indoles bearing a propargyl chloride side chain at the 3-position with various external nucleophiles in the presence of a catalytic amount of Pd₂(dba)₃·CHCl₃/dppb and Cs₂CO₃ in THF gives fused tetracyclic spiroindoles in moderate to good yields.

Original language	English
Pages (from-to)	298-300
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	3
DOIs	https://doi.org/10.1039/c3cc46511j
Publication status	Published - 2014 Dec 3
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "Efficient palladium-catalysed cascade cyclisation to form spiroindoles is developed. Treatment of indoles bearing a propargyl chloride side chain at the 3-position with various external nucleophiles in the presence of a catalytic amount of Pd2(dba)3·CHCl3/dppb and Cs2CO3 in THF gives fused tetracyclic spiroindoles in moderate to good yields.",

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AU - Iwata, Akira

AU - Inuki, Shinsuke

AU - Oishi, Shinya

AU - Fujii, Nobutaka

AU - Ohno, Hiroaki

PY - 2014/12/3

Y1 - 2014/12/3

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AB - Efficient palladium-catalysed cascade cyclisation to form spiroindoles is developed. Treatment of indoles bearing a propargyl chloride side chain at the 3-position with various external nucleophiles in the presence of a catalytic amount of Pd2(dba)3·CHCl3/dppb and Cs2CO3 in THF gives fused tetracyclic spiroindoles in moderate to good yields.

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Synthesis of fused tetracyclic spiroindoles via palladium-catalysed cascade cyclisation

Abstract

ASJC Scopus subject areas

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