Synthesis of glycerolipids containing simple linear acyl chains or aromatic rings and evaluation of their Mincle signaling activity

Takanori Matsumaru, Risa Ikeno, Yusuke Shuchi, Toshiki Iwamatsu, Takashi Tadokoro, Sho Yamasaki, Yukari Fujimoto, Atsushi Furukawa, Katsumi Maenaka

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Mincle, expressed in activated phagocytes, recognizes the lipid ligand to activate the innate immune system. We have synthesized glycerol derivatives possessing simple alkyl chains or aromatic rings and elucidated their structure-activity relationships using a Mincle-mediated signaling assay. The activity depends on the length of the simple acyl chains of the glycerol derivatives.

Original languageEnglish
Pages (from-to)711-714
Number of pages4
JournalChemical Communications
Volume55
Issue number5
DOIs
Publication statusPublished - 2019 Jan 1

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Glycerol
Derivatives
Immune system
Lipids
Assays
Ligands

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Synthesis of glycerolipids containing simple linear acyl chains or aromatic rings and evaluation of their Mincle signaling activity. / Matsumaru, Takanori; Ikeno, Risa; Shuchi, Yusuke; Iwamatsu, Toshiki; Tadokoro, Takashi; Yamasaki, Sho; Fujimoto, Yukari; Furukawa, Atsushi; Maenaka, Katsumi.

In: Chemical Communications, Vol. 55, No. 5, 01.01.2019, p. 711-714.

Research output: Contribution to journalArticle

Matsumaru, Takanori ; Ikeno, Risa ; Shuchi, Yusuke ; Iwamatsu, Toshiki ; Tadokoro, Takashi ; Yamasaki, Sho ; Fujimoto, Yukari ; Furukawa, Atsushi ; Maenaka, Katsumi. / Synthesis of glycerolipids containing simple linear acyl chains or aromatic rings and evaluation of their Mincle signaling activity. In: Chemical Communications. 2019 ; Vol. 55, No. 5. pp. 711-714.
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