Synthesis of (±)-Lasubine II Using N-Methoxyamines

Takashi Yokoyama, Yutaro Fukami, Takaaki Satou, Noritaka Chida

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5 Citations (Scopus)

Abstract

The synthesis of (±)-lasubine II has been achieved through a three-component allylation capitalizing on the unique properties of N-methoxyamines. This reaction enabled the installation of all the carbon atoms of lasubine¯II in a single operation. The N-methoxy group was efficiently used for the subsequent nitrone formation. A single-step cyclization of isoxazolidines or N-methoxyamines to form functionalized piperidine rings was also developed.

Original languageEnglish
Pages (from-to)470-473
Number of pages4
JournalChemistry - An Asian Journal
Volume11
Issue number4
DOIs
Publication statusPublished - 2016 Feb 18

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Keywords

  • allylation
  • amines
  • lasubine
  • multicomponent reactions
  • total synthesis

ASJC Scopus subject areas

  • Chemistry(all)

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