@article{84bd54c8d3f14a489fff533615ad19e7,
title = "Synthesis of lipid A monosaccharide analogues containing acidic amino acid: Exploring the structural basis for the endotoxic and antagonistic activities",
abstract = "For elucidation of the structural and conformational requirements on the endotoxic and antagonistic activity of lipid A derivatives, we designed and synthesized lipid A analogues containing acidic amino acid residues in place of the non-reducing end phosphorylated glucosamine. Definite switching of the endotoxic or antagonistic activity was observed depending on the difference of the acidic groups (phosphoric acid or carboxylic acid) in the lipid A analogues.",
keywords = "Cytokine induction, Endotoxin, IL-6, Innate immunity, Lipid A",
author = "Masao Akamatsu and Yukari Fujimoto and Mikayo Kataoka and Yasuo Suda and Shoichi Kusumoto and Koichi Fukase",
note = "Funding Information: We are grateful to Prof. T. Tamura and Ms. K. Aoyama at Hyogo medical college for their assistance in the cytokine induction assay. We also thank Dr. T. Fujita from Suntory Institute for Bioorganic Research for MS measurements, and Mr. S. Adachi for NMR measurements, and Ms. K. Hayashi and Ms. T. Ikeuchi for elemental analysis at Osaka University. The present work was financially supported in part by Grants-in Aid for Scientific Research (No. 17035050, No. 17310128) from the Japan Society for the Promotion of Science, grants from Suntory Institute for Bioorganic Research (SUNBOR Grant), the Houansha Foundation, and Hayashi Memorial Foundation for Female Natural Scientists (Y.F.). Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",
year = "2006",
month = oct,
day = "1",
doi = "10.1016/j.bmc.2006.05.051",
language = "English",
volume = "14",
pages = "6759--6777",
journal = "Bioorganic and Medicinal Chemistry",
issn = "0968-0896",
publisher = "Elsevier Limited",
number = "19",
}