Synthesis of methyl 1-O-(4-hydroxymethamphetaminyl)-α-D- glucopyranouronate

Rika Nakajima; Machiko Ono; Sadakazu Aiso; Hiroyuki Akita

doi:10.1248/cpb.53.684

Synthesis of methyl 1-O-(4-hydroxymethamphetaminyl)-α-D- glucopyranouronate

Rika Nakajima, Machiko Ono, Sadakazu Aiso, Hiroyuki Akita

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

For the purpose of the direct characterization of the intact conjugated form in the urine of a methamphetamine (MA) abuser, 4-hydroxymethamphetamine (4-OHMA) glucuronate, corresponding to one of the metabolites of MA, was synthesized from the commercially available methyl 4-hydroxyphenylacetate.

Original language	English
Pages (from-to)	684-687
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	53
Issue number	6
DOIs	https://doi.org/10.1248/cpb.53.684
Publication status	Published - 2005 Jun

Keywords

4-hydroxymethamphetamine
Glucuronate
Synthesis

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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10.1248/cpb.53.684

Cite this

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abstract = "For the purpose of the direct characterization of the intact conjugated form in the urine of a methamphetamine (MA) abuser, 4-hydroxymethamphetamine (4-OHMA) glucuronate, corresponding to one of the metabolites of MA, was synthesized from the commercially available methyl 4-hydroxyphenylacetate.",

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author = "Rika Nakajima and Machiko Ono and Sadakazu Aiso and Hiroyuki Akita",

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AU - Nakajima, Rika

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AU - Aiso, Sadakazu

AU - Akita, Hiroyuki

PY - 2005/6

Y1 - 2005/6

N2 - For the purpose of the direct characterization of the intact conjugated form in the urine of a methamphetamine (MA) abuser, 4-hydroxymethamphetamine (4-OHMA) glucuronate, corresponding to one of the metabolites of MA, was synthesized from the commercially available methyl 4-hydroxyphenylacetate.

AB - For the purpose of the direct characterization of the intact conjugated form in the urine of a methamphetamine (MA) abuser, 4-hydroxymethamphetamine (4-OHMA) glucuronate, corresponding to one of the metabolites of MA, was synthesized from the commercially available methyl 4-hydroxyphenylacetate.

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KW - Glucuronate

KW - Synthesis

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Synthesis of methyl 1-O-(4-hydroxymethamphetaminyl)-α-D- glucopyranouronate

Abstract

Keywords

ASJC Scopus subject areas

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