Synthesis of methyl 1-O-(4-hydroxymethamphetaminyl)-α-D- glucopyranouronate

Rika Nakajima, Machiko Ono, Sadakazu Aiso, Hiroyuki Akita

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13 Citations (Scopus)

Abstract

For the purpose of the direct characterization of the intact conjugated form in the urine of a methamphetamine (MA) abuser, 4-hydroxymethamphetamine (4-OHMA) glucuronate, corresponding to one of the metabolites of MA, was synthesized from the commercially available methyl 4-hydroxyphenylacetate.

Original languageEnglish
Pages (from-to)684-687
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume53
Issue number6
DOIs
Publication statusPublished - 2005 Jun

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Keywords

  • 4-hydroxymethamphetamine
  • Glucuronate
  • Synthesis

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

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