Synthesis of methylophiopogonanone a

Ryo Katagiri; Yoshinori Uekusa; Yuji Narukawa; Fumiyuki Kiuchi

doi:10.3987/COM-20-14231

Synthesis of methylophiopogonanone a

Ryo Katagiri, Yoshinori Uekusa, Yuji Narukawa, Fumiyuki Kiuchi

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

Abstract

Ophiopogon Root (root of Ophiopogon japonicus Ker-Gawler, Liliaceae) is a crude drug used as expectorant, anti-cough and tonic in Kampo medicine (traditional Japanese medicine) as well as other traditional medicines of Asian countries. It contains characteristic homoisoflavonoids with methylated ring A. We synthesized methylophiopogonanone A (1), which is a candidate marker compound for identification test of Ophiopogon Root, from phloroglucinol in 9 steps with overall yield of 11.1%.

Original language	English
Pages (from-to)	803-808
Number of pages	6
Journal	Heterocycles
Volume	100
Issue number	5
DOIs	https://doi.org/10.3987/COM-20-14231
Publication status	Published - 2020

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

Access to Document

10.3987/COM-20-14231

Fingerprint Dive into the research topics of 'Synthesis of methylophiopogonanone a'. Together they form a unique fingerprint.

Cite this

@article{4c98d14ef9b74e5fb729a080964f75d5,

title = "Synthesis of methylophiopogonanone a",

abstract = "Ophiopogon Root (root of Ophiopogon japonicus Ker-Gawler, Liliaceae) is a crude drug used as expectorant, anti-cough and tonic in Kampo medicine (traditional Japanese medicine) as well as other traditional medicines of Asian countries. It contains characteristic homoisoflavonoids with methylated ring A. We synthesized methylophiopogonanone A (1), which is a candidate marker compound for identification test of Ophiopogon Root, from phloroglucinol in 9 steps with overall yield of 11.1%.",

author = "Ryo Katagiri and Yoshinori Uekusa and Yuji Narukawa and Fumiyuki Kiuchi",

year = "2020",

doi = "10.3987/COM-20-14231",

language = "English",

volume = "100",

pages = "803--808",

journal = "Heterocycles",

issn = "0385-5414",

publisher = "Japan Institute of Heterocyclic Chemistry",

number = "5",

}

TY - JOUR

T1 - Synthesis of methylophiopogonanone a

AU - Katagiri, Ryo

AU - Uekusa, Yoshinori

AU - Narukawa, Yuji

AU - Kiuchi, Fumiyuki

PY - 2020

Y1 - 2020

N2 - Ophiopogon Root (root of Ophiopogon japonicus Ker-Gawler, Liliaceae) is a crude drug used as expectorant, anti-cough and tonic in Kampo medicine (traditional Japanese medicine) as well as other traditional medicines of Asian countries. It contains characteristic homoisoflavonoids with methylated ring A. We synthesized methylophiopogonanone A (1), which is a candidate marker compound for identification test of Ophiopogon Root, from phloroglucinol in 9 steps with overall yield of 11.1%.

AB - Ophiopogon Root (root of Ophiopogon japonicus Ker-Gawler, Liliaceae) is a crude drug used as expectorant, anti-cough and tonic in Kampo medicine (traditional Japanese medicine) as well as other traditional medicines of Asian countries. It contains characteristic homoisoflavonoids with methylated ring A. We synthesized methylophiopogonanone A (1), which is a candidate marker compound for identification test of Ophiopogon Root, from phloroglucinol in 9 steps with overall yield of 11.1%.

UR - http://www.scopus.com/inward/record.url?scp=85094121964&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85094121964&partnerID=8YFLogxK

U2 - 10.3987/COM-20-14231

DO - 10.3987/COM-20-14231

M3 - Article

AN - SCOPUS:85094121964

VL - 100

SP - 803

EP - 808

JO - Heterocycles

JF - Heterocycles

SN - 0385-5414

IS - 5

ER -