Synthesis of methylophiopogonanone a

Ryo Katagiri; Yoshinori Uekusa; Yuji Narukawa; Fumiyuki Kiuchi

doi:10.3987/COM-20-14231

Synthesis of methylophiopogonanone a

Ryo Katagiri, Yoshinori Uekusa, Yuji Narukawa, Fumiyuki Kiuchi

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

Abstract

Ophiopogon Root (root of Ophiopogon japonicus Ker-Gawler, Liliaceae) is a crude drug used as expectorant, anti-cough and tonic in Kampo medicine (traditional Japanese medicine) as well as other traditional medicines of Asian countries. It contains characteristic homoisoflavonoids with methylated ring A. We synthesized methylophiopogonanone A (1), which is a candidate marker compound for identification test of Ophiopogon Root, from phloroglucinol in 9 steps with overall yield of 11.1%.

Original language	English
Pages (from-to)	803-808
Number of pages	6
Journal	Heterocycles
Volume	100
Issue number	5
DOIs	https://doi.org/10.3987/COM-20-14231
Publication status	Published - 2020

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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10.3987/COM-20-14231

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title = "Synthesis of methylophiopogonanone a",

abstract = "Ophiopogon Root (root of Ophiopogon japonicus Ker-Gawler, Liliaceae) is a crude drug used as expectorant, anti-cough and tonic in Kampo medicine (traditional Japanese medicine) as well as other traditional medicines of Asian countries. It contains characteristic homoisoflavonoids with methylated ring A. We synthesized methylophiopogonanone A (1), which is a candidate marker compound for identification test of Ophiopogon Root, from phloroglucinol in 9 steps with overall yield of 11.1%.",

author = "Ryo Katagiri and Yoshinori Uekusa and Yuji Narukawa and Fumiyuki Kiuchi",

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AU - Katagiri, Ryo

AU - Uekusa, Yoshinori

AU - Narukawa, Yuji

AU - Kiuchi, Fumiyuki

PY - 2020

Y1 - 2020

N2 - Ophiopogon Root (root of Ophiopogon japonicus Ker-Gawler, Liliaceae) is a crude drug used as expectorant, anti-cough and tonic in Kampo medicine (traditional Japanese medicine) as well as other traditional medicines of Asian countries. It contains characteristic homoisoflavonoids with methylated ring A. We synthesized methylophiopogonanone A (1), which is a candidate marker compound for identification test of Ophiopogon Root, from phloroglucinol in 9 steps with overall yield of 11.1%.

AB - Ophiopogon Root (root of Ophiopogon japonicus Ker-Gawler, Liliaceae) is a crude drug used as expectorant, anti-cough and tonic in Kampo medicine (traditional Japanese medicine) as well as other traditional medicines of Asian countries. It contains characteristic homoisoflavonoids with methylated ring A. We synthesized methylophiopogonanone A (1), which is a candidate marker compound for identification test of Ophiopogon Root, from phloroglucinol in 9 steps with overall yield of 11.1%.

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Synthesis of methylophiopogonanone a

Abstract

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