Synthesis of new peptidic glycoclusters derived from β-alanine

Koji Sato, Noriyasu Hada, Tadahiro Takeda

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The synthesis of an asymmetric glycocluster 1 has been achieved by coupling of a sugar unit with the β-alanine polypeptide, the principal chain, and combining a carbohydrate chain with the side chain causing it to branch from the N terminal. The synthesis of this side chain multivalent ligands is based on the scaffolding of some ω-amino acid (glycine, β-alanine, and GABA) derivatives. This method facilitated the synthesis of the cluster, of which the length of each unit differs.

Original languageEnglish
Pages (from-to)9331-9335
Number of pages5
JournalTetrahedron Letters
Volume44
Issue number52
DOIs
Publication statusPublished - 2003 Dec 22

Fingerprint

Alanine
Glycine
gamma-Aminobutyric Acid
Carbohydrates
Ligands
Amino Acids
Sugars
Peptides
Derivatives
coupling sugar

Keywords

  • β-peptide
  • Carbohydrate- protein interaction
  • D-galactose
  • Glycocluster
  • Unit synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Synthesis of new peptidic glycoclusters derived from β-alanine. / Sato, Koji; Hada, Noriyasu; Takeda, Tadahiro.

In: Tetrahedron Letters, Vol. 44, No. 52, 22.12.2003, p. 9331-9335.

Research output: Contribution to journalArticle

Sato, Koji ; Hada, Noriyasu ; Takeda, Tadahiro. / Synthesis of new peptidic glycoclusters derived from β-alanine. In: Tetrahedron Letters. 2003 ; Vol. 44, No. 52. pp. 9331-9335.
@article{88fa598360ce40cfb6187936454607c1,
title = "Synthesis of new peptidic glycoclusters derived from β-alanine",
abstract = "The synthesis of an asymmetric glycocluster 1 has been achieved by coupling of a sugar unit with the β-alanine polypeptide, the principal chain, and combining a carbohydrate chain with the side chain causing it to branch from the N terminal. The synthesis of this side chain multivalent ligands is based on the scaffolding of some ω-amino acid (glycine, β-alanine, and GABA) derivatives. This method facilitated the synthesis of the cluster, of which the length of each unit differs.",
keywords = "β-peptide, Carbohydrate- protein interaction, D-galactose, Glycocluster, Unit synthesis",
author = "Koji Sato and Noriyasu Hada and Tadahiro Takeda",
year = "2003",
month = "12",
day = "22",
doi = "10.1016/j.tetlet.2003.10.073",
language = "English",
volume = "44",
pages = "9331--9335",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "52",

}

TY - JOUR

T1 - Synthesis of new peptidic glycoclusters derived from β-alanine

AU - Sato, Koji

AU - Hada, Noriyasu

AU - Takeda, Tadahiro

PY - 2003/12/22

Y1 - 2003/12/22

N2 - The synthesis of an asymmetric glycocluster 1 has been achieved by coupling of a sugar unit with the β-alanine polypeptide, the principal chain, and combining a carbohydrate chain with the side chain causing it to branch from the N terminal. The synthesis of this side chain multivalent ligands is based on the scaffolding of some ω-amino acid (glycine, β-alanine, and GABA) derivatives. This method facilitated the synthesis of the cluster, of which the length of each unit differs.

AB - The synthesis of an asymmetric glycocluster 1 has been achieved by coupling of a sugar unit with the β-alanine polypeptide, the principal chain, and combining a carbohydrate chain with the side chain causing it to branch from the N terminal. The synthesis of this side chain multivalent ligands is based on the scaffolding of some ω-amino acid (glycine, β-alanine, and GABA) derivatives. This method facilitated the synthesis of the cluster, of which the length of each unit differs.

KW - β-peptide

KW - Carbohydrate- protein interaction

KW - D-galactose

KW - Glycocluster

KW - Unit synthesis

UR - http://www.scopus.com/inward/record.url?scp=0345304276&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0345304276&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2003.10.073

DO - 10.1016/j.tetlet.2003.10.073

M3 - Article

AN - SCOPUS:0345304276

VL - 44

SP - 9331

EP - 9335

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 52

ER -