The synthesis of an asymmetric glycocluster 1 has been achieved using two glycocluster units 12 and 13, prepared by coupling the cluster chain unit 4 with each ω-amino acid (β-alanine and 6-aminocapronic acid) trichloroethyl ester, and peptidic C-terminal block glycocluster 16, prepared by coupling the bifunctional linker 14 with sugar unit 9. This method facilitated the synthesis of the cluster optionally modulated the distance between the side-chain branched points by using various ω-amino acids. We also synthesized glycodendron 2 using the same intermediate.
|Number of pages||5|
|Journal||Chemical and Pharmaceutical Bulletin|
|Publication status||Published - 2005 Sept|
- Unit synthesis
- ω-amino acid
ASJC Scopus subject areas
- Drug Discovery