Synthesis of new peptidic glycoclusters derived from β-alanine. Part 2: Optionally modulated distance between side-chain branched points

Noriyasu Hada, Koji Sato, Yuhua Jin, Tadahiro Takeda

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The synthesis of an asymmetric glycocluster 1 has been achieved using two glycocluster units 12 and 13, prepared by coupling the cluster chain unit 4 with each ω-amino acid (β-alanine and 6-aminocapronic acid) trichloroethyl ester, and peptidic C-terminal block glycocluster 16, prepared by coupling the bifunctional linker 14 with sugar unit 9. This method facilitated the synthesis of the cluster optionally modulated the distance between the side-chain branched points by using various ω-amino acids. We also synthesized glycodendron 2 using the same intermediate.

Original languageEnglish
Pages (from-to)1131-1135
Number of pages5
JournalChemical and Pharmaceutical Bulletin
Volume53
Issue number9
DOIs
Publication statusPublished - 2005 Sep

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Alanine
Amino Acids
Sugars
Esters
Acids
calcium ascorbate

Keywords

  • ω-amino acid
  • D-galactose
  • Glycocluster
  • Glycodendron
  • Unit synthesis

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Cite this

Synthesis of new peptidic glycoclusters derived from β-alanine. Part 2 : Optionally modulated distance between side-chain branched points. / Hada, Noriyasu; Sato, Koji; Jin, Yuhua; Takeda, Tadahiro.

In: Chemical and Pharmaceutical Bulletin, Vol. 53, No. 9, 09.2005, p. 1131-1135.

Research output: Contribution to journalArticle

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