Abstract
A convergent synthesis of the ABC ring of antitumor natural product paclitaxel (Taxol) is described. SmI2-mediated reductive cyclization of an allylic benzoate possessing an aldehyde function, synthesized from tri-O-acetyl-d-glucal and 1,3-cyclohexanedione, smoothly afforded the highly strained 6-8-6 tricarbocyclic structure in 66% yield.
Original language | English |
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Pages (from-to) | 2570-2573 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 17 |
Issue number | 11 |
DOIs | |
Publication status | Published - 2015 Jun 5 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry